PDF(Pubmed)
Abstract：
(1) Background: This prospective study aimed to assess the impact on quality of life (QoL) from pretreatment to 3 years after treatment in oropharyngeal carcinoma (OPC) survivors. (2) Methods: QoL was measured with the EORTC QLQ-C30 and EORTC QLQ-H&N35 scales before treatment and in the first and third years. (3) Results: Of 72 patients, 51 completed all questionnaires over 3 years. A variable deterioration of QoL scores was detected before treatment. Most items worsened significantly after treatment and during the first year and improved in the third year. Advanced-stage cancer and definitive chemoradiotherapy treatment showed the worst scores. At 3 years, patients who underwent surgery with adjuvant radiation therapy/chemotherapy had significantly better scores on global QoL and emotional functioning compared to those treated with definitive chemoradiotherapy, who also reported problems with sticky salivation and dry mouth. Patients treated with an open surgical approach showed significantly greater deterioration in physical and role functioning compared to transoral surgery. (4) Conclusions: This long-term prospective study is the first in Spain to use EORCT scales in a homogeneous group of OPC survivors. QoL was generally good, although patients needed a long period of time to recover from both cancer and side effects of treatment. Advanced-stage cancer and definitive chemoradiotherapy showed the worst scores.
摘要：
（1）背景：这项前瞻性研究旨在评估口咽癌（OPC）幸存者从治疗前到治疗后3年对生活质量（QoL）的影响。(2)方法:治疗前、第1年和第3年采用EORTCQLQ-C30和EORTCQLQ-H&N35量表测定QoL。（3）结果：72例患者中，51人在3年内完成了所有问卷。治疗前检测到QoL评分的可变恶化。大多数项目在治疗后和第一年明显恶化，第三年有所改善。晚期癌症和确定性放化疗治疗得分最差。三年后，与接受确定性放化疗治疗的患者相比，接受辅助放疗/化疗手术的患者在总体QoL和情绪功能方面的得分明显更好，他还报告了唾液粘稠和口干的问题。与经口手术相比，采用开放式手术方法治疗的患者在身体和角色功能方面表现出明显更大的恶化。（4）结论：这项长期前瞻性研究是西班牙首次在OPC幸存者的同质组中使用EORCT量表。QoL总体良好，尽管患者需要很长时间才能从癌症和治疗副作用中恢复过来。晚期癌症和确定性放化疗的得分最差。
