PDF(Pubmed)
Abstract：
Breast cancer is a significant global issue, ranking as the second most common cancer among women worldwide and a leading cause of cancer-related deaths. Although the exact causes of this increase remain unclear, factors such as genetics, epigenetics, obesity, sedentary lifestyle, tobacco use, and vitamin D deficiency have been implicated. The Toll-like receptor 9 (TLR9) is recognized for its role in inflammation and innate immunity; however, its specific involvement in breast cancer pathogenesis requires further investigation. This study aims to systematically review the existing literature on TLR9 expression in normal and cancerous breast tissue, providing current knowledge and identifying gaps. Relevant articles in English were from PubMed, Scopus, and Google Scholar, with the inclusion criteria focusing on studies evaluating TLR9 mRNA and protein expression. The review found that TLR9 mRNA and protein exhibit variable expressions in both normal and cancerous breast tissue, highlighting the need for further research to clarify TLR9\'s role in breast cancer.
摘要：
乳腺癌是一个重要的全球性问题，在全球女性中排名第二，是癌症相关死亡的主要原因。尽管这种增加的确切原因尚不清楚，遗传等因素，表观遗传学,肥胖，久坐的生活方式，烟草使用,和维生素D缺乏也有牵连。Toll样受体9(TLR9)因其在炎症和先天免疫中的作用而被公认;然而,其在乳腺癌发病机制中的具体参与需要进一步研究。本研究旨在对TLR9在正常乳腺组织和癌变乳腺组织中的表达进行系统综述,提供当前知识并确定差距。相关的英文文章来自PubMed,Scopus,和谷歌学者，纳入标准侧重于评估TLR9mRNA和蛋白表达的研究。该综述发现，TLR9mRNA和蛋白在正常和癌变乳腺组织中均表现出不同的表达，强调需要进一步研究以阐明TLR9在乳腺癌中的作用。
