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Abstract：
Colorectal cancer (CRC) represents a significant global healthcare burden, with a particularly concerning rising incidence among younger adults. This trend may highlight potential links between diet, gut microbiome, and CRC risk. Novel therapeutic options have been increasingly based on the understanding of molecular mechanisms and pathways. The PI3K/AKT/mTOR pathway, a crucial cell growth regulator, offers a promising target for CRC therapy. mTOR, a key component within this pathway, controls cell growth, survival, and metabolism. Understanding the specific roles of defensins, particularly human β-Defensin 1 (HBD-1), in CRC is crucial. HBD-1 exhibits potent antimicrobial activity and may influence CRC development. Deciphering defensin expression patterns in CRC holds the promise of improved understanding of tumorigenesis, which may pave the way for improved diagnostics and therapies. This article reviews recent advances in understanding regarding how HBD-1 influences CRC initiation and progression, highlighting the molecular mechanisms by which it impacts CRC. Further, we describe the interaction between defensins and mTOR pathway in CRC.
摘要：
结直肠癌(CRC)是一个巨大的全球医疗保健负担。尤其令人担忧的是，年轻人的发病率上升。这种趋势可能凸显了饮食之间的潜在联系，肠道微生物组，CRC风险。新的治疗选择越来越基于对分子机制和途径的理解。PI3K/AKT/mTOR通路,一个至关重要的细胞生长调节剂，为CRC治疗提供了一个有希望的目标。mTOR,这条途径中的一个关键组成部分，控制细胞生长，生存,和新陈代谢。了解防御素的具体作用，特别是人β-防御素1（HBD-1），在CRC中至关重要。HBD-1表现出有效的抗微生物活性，并可能影响CRC的发展。破译CRC中的防御素表达模式有望改善对肿瘤发生的理解。这可能为改进诊断和治疗铺平道路。本文回顾了有关HBD-1如何影响CRC开始和进展的最新进展。强调其影响CRC的分子机制。Further,我们描述了CRC中防御素和mTOR通路之间的相互作用。
