PDF(Pubmed)
Abstract：
Prostate cancer is the most common cancer diagnosed in men and the second leading cause of death in male cancer patients. The WHO suggests that cobalt is involved in the carcinogenesis of prostate cancer. There are, however, no studies associating cobalt levels and prostate cancer patient survival. In this study, 261 Polish prostate cancer (n = 261) patients were recruited into a prospective cohort between 2009 and 2015. Serum cobalt levels were measured using ICP-MS after prostate cancer diagnosis and before treatment. All study participants were assigned into quartiles (QI-QIV) based on the distribution of serum cobalt levels among censored patients. Univariable and multivariable COX regression models were used to calculate hazard ratios (HRs) for each serum cobalt level quartile. We found a significant relationship between high serum cobalt levels and poor prostate cancer patient total survival (HR = 2.60; 95% CI: 1.17-5.82; p = 0.02). In relation to prostate cancer patients who died as a result of other non-cancer causes, the association with high levels of cobalt was even stronger (HR = 3.67; 95% CI: 1.03-13.00; p = 0.04). The impact of high serum cobalt levels on overall survival of prostate cancer-specific-related deaths was not statistically significant.
摘要：
前列腺癌是男性最常见的癌症，也是男性癌症患者死亡的第二大原因。WHO提示钴参与前列腺癌的发生。有,然而,没有研究将钴水平与前列腺癌患者的生存率相关联。在这项研究中,在2009年至2015年之间，招募了261名波兰前列腺癌患者（n=261）进入前瞻性队列。在前列腺癌诊断后和治疗前使用ICP-MS测量血清钴水平。所有研究参与者根据删失患者中血清钴水平的分布被分配到四分位数（QI-QIV）。使用单变量和多变量COX回归模型来计算每个血清钴水平四分位数的风险比（HR）。我们发现高血清钴水平与前列腺癌患者总生存率之间存在显着关系（HR=2.60；95％CI：1.17-5.82；p=0.02）。对于因其他非癌症原因而死亡的前列腺癌患者，与高钴含量的相关性更强(HR=3.67;95%CI:1.03-13.00;p=0.04).高血清钴水平对前列腺癌特异性相关死亡总生存期的影响无统计学意义。
