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Abstract：
This study investigated the association between serum albumin concentration and 12-weeks mortality of HIV/AIDS with late diagnosis in China. This retrospective cohort study included, 1079 inpatients diagnosis with late HIV/AIDS between January 2018 and December 2021. Disease progression was estimated based on the 12-weeks mortality rate. Cox proportional hazards regression models were used to evaluate the relationship between serum albumin levels and disease progression. The effects of serum albumin levels on mortality was estimated via Kaplan-Meier curves. The mortality risk decreased by 7% with every 1 g/L increase in serum albumin after adjustment ([HR] = 0.93, 95% CI: 0.88-0.97). Compared with that of the low (< 28 g/L) serum albumin group, the middle (28-34 g/L) group\'s mortality risk decreased by 70% (HR = 0.30, 95% CI: 0.15-0.59), and that of the high (≥ 34 g/L) group decreased by 40% (HR = 0.6, 95% CI: 0.29-1.23) after adjustment. Our findings suggest a positive correlation between the increase in serum albumin levels upon admission and a decrease in mortality at 12 weeks post-discharge among patients with late AIDS/HIV diagnosis. Further research is needed to characterize the role of serum albumin in 12-weeks mortality prevention in patients with a late diagnosis.
摘要：
这项研究调查了血清白蛋白浓度与中国晚期诊断的HIV/AIDS12周死亡率之间的关系。这项回顾性队列研究包括，2018年1月至2021年12月期间，1079名住院患者诊断为晚期HIV/AIDS。根据12周死亡率估计疾病进展。Cox比例风险回归模型用于评估血清白蛋白水平与疾病进展之间的关系。通过Kaplan-Meier曲线估计血清白蛋白水平对死亡率的影响。调整后血清白蛋白每增加1g/L，死亡风险降低7％（[HR]=0.93，95％CI：0.88-0.97）。与低（<28g/L）血清白蛋白组相比，中等（28-34g/L）组的死亡风险降低了70％（HR=0.30，95％CI：0.15-0.59），调整后，高（≥34g/L）组下降了40％（HR=0.6，95％CI：0.29-1.23）。我们的发现表明，在晚期AIDS/HIV诊断患者中，入院时血清白蛋白水平的升高与出院后12周死亡率的降低之间呈正相关。需要进一步的研究来表征血清白蛋白在晚期诊断患者12周死亡率预防中的作用。
