LAG - 3 和 PD - 1 的阻断导致 CD8 + T 细胞中细胞毒性和耗竭基因模块的共表达以促进抗肿瘤免疫。
关键词: CD8(+) T cell transcriptional profiles LAG-3 PD-1 T cell exhaustion advanced melanoma antitumor immunity checkpoint blockade combination immunotherapy inhibitory receptors
Mesh : Humans Antigens, CD / metabolism genetics Basic-Leucine Zipper Transcription Factors / metabolism genetics CD8-Positive T-Lymphocytes / immunology metabolism Cell Differentiation Cytotoxicity, Immunologic High Mobility Group Proteins Immune Checkpoint Inhibitors / therapeutic use pharmacology Lymphocyte Activation Gene 3 Protein / antagonists & inhibitors Melanoma / immunology drug therapy genetics Nivolumab / therapeutic use pharmacology Positive Regulatory Domain I-Binding Factor 1 / metabolism genetics Programmed Cell Death 1 Receptor / antagonists & inhibitors Signal Transduction
来 源:
DOI:10.1016/j.cell.2024.06.036
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