LAG - 3 和 PD - 1 在 CD8 + T 细胞上协同作用以驱动 T 细胞耗尽并阻碍自分泌 IFN - γ 依赖性抗肿瘤免疫。
关键词: CD8(+) T cell IFN-γ NKG2A anti-LAG-3 anti-PD-1 anti-tumor immunity immune checkpoint inhibitor immuno-oncology immunotherapy melanoma
Mesh : Lymphocyte Activation Gene 3 Protein Programmed Cell Death 1 Receptor / metabolism CD8-Positive T-Lymphocytes / immunology metabolism Animals Interferon-gamma / metabolism Mice Mice, Inbred C57BL Antigens, CD / metabolism Autocrine Communication Humans Melanoma / immunology drug therapy Female Cell Line, Tumor Melanoma, Experimental / immunology T-Cell Exhaustion
来 源:
DOI:10.1016/j.cell.2024.07.016
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