LAG - 3 维持 TOX 表达并调节 CD94 / NKG2 - Qa - 1b 轴以控制耗尽的 CD8 T 细胞 NK 受体表达和细胞毒性。
关键词: CD94 LAG-3 NKG2 NKG2A PD-1 Qa-1b T cell exhaustion TOX cancer immunosurveillance
Mesh : Lymphocyte Activation Gene 3 Protein Animals Antigens, CD / metabolism CD8-Positive T-Lymphocytes / immunology metabolism Mice Programmed Cell Death 1 Receptor / metabolism NK Cell Lectin-Like Receptor Subfamily D / metabolism Histocompatibility Antigens Class I / metabolism Humans NK Cell Lectin-Like Receptor Subfamily C / metabolism Mice, Inbred C57BL High Mobility Group Proteins / metabolism genetics Cytotoxicity, Immunologic Cell Proliferation Killer Cells, Natural / metabolism immunology
来 源:
DOI:10.1016/j.cell.2024.07.018
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