PDF(Pubmed)
Abstract：
BACKGROUND: Depersonalisation-Derealisation Disorder (DDD) is a distressing mental health condition which causes individuals to have a sense of \'unreality\' or detachment about themselves and/or the world around them. DDD is chronically under-researched, and as a result, under-diagnosed, with a population prevalence of about 1%. In systematic reviews, Cognitive Behavioural Therapy (CBT) has been found to be the only intervention with significant clinical impact on alleviating the symptoms of DDD. However, previous studies have suffered from small sample sizes, reliance on expert clinicians to provide therapy and narrow population demographics. This feasibility randomised controlled trial aims to provide more robust evidence for the treatment efficacy of CBT in DDD.
METHODS: The study aims to recruit 40 participants from two NHS trusts, 20 per arm from two community Mental Health NHS services in London. The intervention group will receive 12-24 individual CBT sessions over a 6-month period from CBT therapists following specialist training for DDD. The control group will receive Treatment as Usual. We will assess the feasibility of a future RCT through measuring the acceptability of the intervention, and assessing our ability to recruit, retain and randomise participants. We will calculate the correlation of scores on the Cambridge Depersonalisation Scale, its baseline standard deviation, assess the magnitude/direction of change and characterise the uncertainty in the outcome scores and the probability that the results have been obtained by chance.
CONCLUSIONS: The outputs of this trial will guide whether a definite RCT is feasible and acceptable, for both the clinician and participant.
BACKGROUND: The ISRCTN registration number is ISRCTN97686121(https://doi.org/10.1186/ISRCTN97686121).
METHODS: The study aims to recruit 40 participants from two NHS trusts, 20 per arm from two community Mental Health NHS services in London. The intervention group will receive 12-24 individual CBT sessions over a 6-month period from CBT therapists following specialist training for DDD. The control group will receive Treatment as Usual. We will assess the feasibility of a future RCT through measuring the acceptability of the intervention, and assessing our ability to recruit, retain and randomise participants. We will calculate the correlation of scores on the Cambridge Depersonalisation Scale, its baseline standard deviation, assess the magnitude/direction of change and characterise the uncertainty in the outcome scores and the probability that the results have been obtained by chance.
CONCLUSIONS: The outputs of this trial will guide whether a definite RCT is feasible and acceptable, for both the clinician and participant.
BACKGROUND: The ISRCTN registration number is ISRCTN97686121(https://doi.org/10.1186/ISRCTN97686121).
摘要：
背景：去人格化-去人格化障碍（DDD）是一种令人痛苦的精神健康状况，它使个人对自己和/或周围的世界产生“不现实”或超然感。DDD长期研究不足，结果，诊断不足，人口患病率约为1%。在系统审查中，已发现认知行为疗法（CBT）是唯一对减轻DDD症状具有显着临床影响的干预措施。然而,以前的研究样本量小，依靠专家临床医生提供治疗和狭窄的人口统计。这项可行性随机对照试验旨在为CBT治疗DDD的疗效提供更有力的证据。
方法：该研究旨在从两个NHS信托中招募40名参与者，伦敦两个社区心理健康NHS服务的每个手臂20个。在接受DDD专业培训后，干预组将在6个月内从CBT治疗师那里接受12-24次单独的CBT课程。对照组将接受常规治疗。我们将通过衡量干预措施的可接受性来评估未来RCT的可行性，评估我们的招募能力，保留和随机化参与者。我们将计算剑桥去个性化量表上分数的相关性，其基线标准偏差，评估变化的幅度/方向，并描述结果评分的不确定性以及偶然获得结果的可能性。
结论：本试验的结果将指导确定的RCT是否可行和可接受，对于临床医生和参与者来说。
背景：ISRCTN的注册号是ISRCTN97686121（https://doi.org/10.1186/ISRCTN97686121）。
方法：该研究旨在从两个NHS信托中招募40名参与者，伦敦两个社区心理健康NHS服务的每个手臂20个。在接受DDD专业培训后，干预组将在6个月内从CBT治疗师那里接受12-24次单独的CBT课程。对照组将接受常规治疗。我们将通过衡量干预措施的可接受性来评估未来RCT的可行性，评估我们的招募能力，保留和随机化参与者。我们将计算剑桥去个性化量表上分数的相关性，其基线标准偏差，评估变化的幅度/方向，并描述结果评分的不确定性以及偶然获得结果的可能性。
结论：本试验的结果将指导确定的RCT是否可行和可接受，对于临床医生和参与者来说。
背景：ISRCTN的注册号是ISRCTN97686121（https://doi.org/10.1186/ISRCTN97686121）。
