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Abstract：
BACKGROUND: Skin neoplasms, particularly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are prevalent forms of skin malignancies. To enhance accurate diagnosis, non-invasive techniques including high-frequency ultrasound (HFUS) are crucial. HFUS offers deeper penetration compared to reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), making it valuable for examining skin structures. The aim of this study was to investigate and diagnose localized manifestation of BCC and SCC with HFUS and compare it with pathology results in patients referred to Razi Hospital, Tehran, Iran.
METHODS: This study included patients diagnosed with BCC and SCC, with clinical and pathological confirmation, attending the oncology clinic of Razi Hospital, Tehran, Iran, from 2022 to 2023. Exclusion criteria comprised metastatic and recurrent cases, patients who underwent treatment or surgery, and tumors located in anatomically challenging areas. HFUS with a 20 MHz probe and Doppler ultrasound were employed to examine the skin. Tumors were subsequently excised, fixed in formalin, and sent for pathological assessment. Ultrasound findings were compared with pathology results.
RESULTS: The study assessed 40 patients, with half diagnosed with SCC and the other half with BCC. The majority of SCC patients were male (80%), while BCC patients were relatively evenly divided between males (65%) and females (35%). The mean age was 59.15 ± 11.9 years for SCC and 63.4 ± 8.9 years for BCC. Cheeks (20%) and lips (35%) were the most common sampling sites for BCC and SCC, respectively. The correlation coefficients for tumor size and depth between ultrasound and pathology were 0.981 and 0.912, respectively, indicating a high level of agreement between the two methods.
CONCLUSIONS: In BCC patients, there was complete agreement between sonographic loco-regional extension and pathology findings. However, some discordance (30%) was observed in SCC cases. The study demonstrated a strong correlation between ultrasound and pathology in accurately detecting the depth and extent of the tumor. However, due to the inclusion of only patients with positive pathology, it is not appropriate to evaluate the diagnostic test values and compare them with pathology results. Therefore, it is highly recommended to carry out additional studies with larger sample sizes to further validate these findings.
METHODS: This study included patients diagnosed with BCC and SCC, with clinical and pathological confirmation, attending the oncology clinic of Razi Hospital, Tehran, Iran, from 2022 to 2023. Exclusion criteria comprised metastatic and recurrent cases, patients who underwent treatment or surgery, and tumors located in anatomically challenging areas. HFUS with a 20 MHz probe and Doppler ultrasound were employed to examine the skin. Tumors were subsequently excised, fixed in formalin, and sent for pathological assessment. Ultrasound findings were compared with pathology results.
RESULTS: The study assessed 40 patients, with half diagnosed with SCC and the other half with BCC. The majority of SCC patients were male (80%), while BCC patients were relatively evenly divided between males (65%) and females (35%). The mean age was 59.15 ± 11.9 years for SCC and 63.4 ± 8.9 years for BCC. Cheeks (20%) and lips (35%) were the most common sampling sites for BCC and SCC, respectively. The correlation coefficients for tumor size and depth between ultrasound and pathology were 0.981 and 0.912, respectively, indicating a high level of agreement between the two methods.
CONCLUSIONS: In BCC patients, there was complete agreement between sonographic loco-regional extension and pathology findings. However, some discordance (30%) was observed in SCC cases. The study demonstrated a strong correlation between ultrasound and pathology in accurately detecting the depth and extent of the tumor. However, due to the inclusion of only patients with positive pathology, it is not appropriate to evaluate the diagnostic test values and compare them with pathology results. Therefore, it is highly recommended to carry out additional studies with larger sample sizes to further validate these findings.
摘要：
背景：皮肤肿瘤，特别是基底细胞癌（BCC）和鳞状细胞癌（SCC），是皮肤恶性肿瘤的常见形式。为了提高诊断的准确性，包括高频超声(HFUS)在内的非侵入性技术至关重要.与反射共聚焦显微镜（RCM）相比，HFUS具有更深的穿透力，光学相干断层扫描（OCT），使其对检查皮肤结构有价值。这项研究的目的是调查和诊断与HFUS的BCC和SCC的局部表现，并将其与转诊到Razi医院的患者的病理结果进行比较。德黑兰,伊朗。
方法：本研究包括诊断为BCC和SCC的患者，经临床和病理证实，参加了拉齐医院的肿瘤诊所，德黑兰,伊朗,从2022年到2023年。排除标准包括转移性和复发性病例，接受治疗或手术的患者，和位于解剖学挑战性区域的肿瘤。使用具有20MHz探头和多普勒超声的HFUS检查皮肤。随后切除肿瘤，固定在福尔马林中，送去做病理评估.将超声检查结果与病理结果进行比较。
结果：该研究评估了40名患者，一半诊断为SCC，另一半诊断为BCC。大多数SCC患者为男性（80％），而BCC患者在男性（65％）和女性（35％）之间相对平均。SCC的平均年龄为59.15±11.9岁，BCC的平均年龄为63.4±8.9岁。脸颊（20％）和嘴唇（35％）是BCC和SCC最常见的采样部位，分别。超声与病理对肿瘤大小和深度的相关系数分别为0.981和0.912,表明两种方法之间的高度一致性。
结论：在BCC患者中，超声检查局部区域扩展和病理结果完全一致.然而,在SCC病例中观察到一些不一致(30%).该研究表明，在准确检测肿瘤的深度和范围方面，超声和病理学之间存在很强的相关性。然而,由于只包括病理阳性的患者，评估诊断测试值并将其与病理结果进行比较是不合适的。因此,强烈建议开展更多样本量更大的研究,以进一步验证这些发现.
方法：本研究包括诊断为BCC和SCC的患者，经临床和病理证实，参加了拉齐医院的肿瘤诊所，德黑兰,伊朗,从2022年到2023年。排除标准包括转移性和复发性病例，接受治疗或手术的患者，和位于解剖学挑战性区域的肿瘤。使用具有20MHz探头和多普勒超声的HFUS检查皮肤。随后切除肿瘤，固定在福尔马林中，送去做病理评估.将超声检查结果与病理结果进行比较。
结果：该研究评估了40名患者，一半诊断为SCC，另一半诊断为BCC。大多数SCC患者为男性（80％），而BCC患者在男性（65％）和女性（35％）之间相对平均。SCC的平均年龄为59.15±11.9岁，BCC的平均年龄为63.4±8.9岁。脸颊（20％）和嘴唇（35％）是BCC和SCC最常见的采样部位，分别。超声与病理对肿瘤大小和深度的相关系数分别为0.981和0.912,表明两种方法之间的高度一致性。
结论：在BCC患者中，超声检查局部区域扩展和病理结果完全一致.然而,在SCC病例中观察到一些不一致(30%).该研究表明，在准确检测肿瘤的深度和范围方面，超声和病理学之间存在很强的相关性。然而,由于只包括病理阳性的患者，评估诊断测试值并将其与病理结果进行比较是不合适的。因此,强烈建议开展更多样本量更大的研究,以进一步验证这些发现.
