Abstract：
UNASSIGNED: Staphylococcus aureus bacteraemia (SAB) may lead to periprosthetic joint infections (PJI) via haematogenous spread of bacteria to the joint. Due to the risk of PJI, patients with SAB and prosthetic joint are recommended prolonged antibiotic treatment. The aim of the study was to assess the risk of PJI during SAB, and to evaluate if short treatment duration affects outcomes in patients with uncomplicated SAB and prosthetic joints without clinical signs of PJI.
UNASSIGNED: Patients with growth of S. aureus in blood cultures were cross-referenced against the Swedish Arthroplasty register to identify patients with prosthetic hip or knee joints at the time of SAB. Medical records were reviewed to identify PJI at the time of SAB and during a 6-month follow-up period.
UNASSIGNED: Out of 400 patients with SAB and a prosthetic joint, 281 met all eligibility criteria and were included in the study. Of the included participants, 35 (12%) had a haematogenous PJI. Younger age and presence of multiple prosthetic joints were associated with an increased risk of PJI. Of the 247 patients without signs of PJI at the initial SAB episode, 118 patients (48%) had an uncomplicated infection and received short total antibiotic treatment (median 15 days, IQR 13-17). The risk of PJI during the follow-up period was low (<1%) and similar in the uncomplicated group compared to patients with complicated SAB that received longer antibiotic treatment (median 29 days, IQR 15-70).
UNASSIGNED: The prevalence of haematogenous PJI was lower than previously reported. Our data do not support prolonged antibiotic treatment in patients with SAB and prosthetic joints without clinical signs of PJI.
UNASSIGNED: Patients with growth of S. aureus in blood cultures were cross-referenced against the Swedish Arthroplasty register to identify patients with prosthetic hip or knee joints at the time of SAB. Medical records were reviewed to identify PJI at the time of SAB and during a 6-month follow-up period.
UNASSIGNED: Out of 400 patients with SAB and a prosthetic joint, 281 met all eligibility criteria and were included in the study. Of the included participants, 35 (12%) had a haematogenous PJI. Younger age and presence of multiple prosthetic joints were associated with an increased risk of PJI. Of the 247 patients without signs of PJI at the initial SAB episode, 118 patients (48%) had an uncomplicated infection and received short total antibiotic treatment (median 15 days, IQR 13-17). The risk of PJI during the follow-up period was low (<1%) and similar in the uncomplicated group compared to patients with complicated SAB that received longer antibiotic treatment (median 29 days, IQR 15-70).
UNASSIGNED: The prevalence of haematogenous PJI was lower than previously reported. Our data do not support prolonged antibiotic treatment in patients with SAB and prosthetic joints without clinical signs of PJI.
摘要：
■金黄色葡萄球菌菌血症（SAB）可能通过细菌向关节的血源性传播导致关节假体周围感染（PJI）。由于PJI的风险，SAB和人工关节患者建议延长抗生素治疗.该研究的目的是评估SAB期间PJI的风险，并评估短治疗时间是否影响无PJI临床体征的无并发症SAB和假体关节患者的预后。
■将血液培养中金黄色葡萄球菌生长的患者与瑞典关节成形术注册进行交叉对照，以确定SAB时患有假体髋关节或膝关节的患者。在SAB时和6个月的随访期间，对医疗记录进行了审查，以确定PJI。
■在400名SAB和假肢关节患者中，281符合所有资格标准，并被纳入研究。在包括的参与者中，35（12％）患有血源性PJI。年龄较小和多个假体关节的存在与PJI的风险增加有关。在最初的SAB发作中没有PJI体征的247例患者中，118例患者（48%）无并发症感染，并接受短期总抗生素治疗（中位数为15天，IQR13-17).随访期间PJI的风险较低（<1％），与接受更长抗生素治疗的复杂SAB患者相比，无并发症组的PJI风险相似（中位数29天，IQR15-70）。
■血源性PJI的患病率低于以前的报道。我们的数据不支持在没有PJI临床体征的SAB和假体关节患者中延长抗生素治疗。
■将血液培养中金黄色葡萄球菌生长的患者与瑞典关节成形术注册进行交叉对照，以确定SAB时患有假体髋关节或膝关节的患者。在SAB时和6个月的随访期间，对医疗记录进行了审查，以确定PJI。
■在400名SAB和假肢关节患者中，281符合所有资格标准，并被纳入研究。在包括的参与者中，35（12％）患有血源性PJI。年龄较小和多个假体关节的存在与PJI的风险增加有关。在最初的SAB发作中没有PJI体征的247例患者中，118例患者（48%）无并发症感染，并接受短期总抗生素治疗（中位数为15天，IQR13-17).随访期间PJI的风险较低（<1％），与接受更长抗生素治疗的复杂SAB患者相比，无并发症组的PJI风险相似（中位数29天，IQR15-70）。
■血源性PJI的患病率低于以前的报道。我们的数据不支持在没有PJI临床体征的SAB和假体关节患者中延长抗生素治疗。
