METHODS: We obtained high-resolution T1-weighted (T1w) and T2-weighted (T2w) MRI images using 7T scanners located at three sites in two countries: Pittsburgh (n = 14) and Texas (San Antonio and Houston) (n = 40) in the USA, and Nottingham, UK (n = 33). We evaluated the hippocampus subfields using the ASHS package [1-3]. Imaging sets of 51 subjects with minimal or no manual segmentation corrections (Figures 1 and 2) were included in the analysis. We conducted T-tests with Bonferroni correction, adjusting for age and intracranial volume to identify the differences in hippocampus subfield volumes across groups.
RESULTS: Participants who needed admission into the ICU due to Covid-19 showed a significantly lower (p-value = 0.0034) left CA1 volume compared to participants who did not require ICU (Figure 3). In addition, several other non-significant trends were observed.
CONCLUSIONS: Our preliminary findings suggest that Covid-19 may impact the hippocampus, particularly in patients who required intensive care. However, the study - as of to date - has a small sample size and lacks a comparison group with patients who were admitted into ICU for acute illnesses other than Covid-19. Additionally, longitudinal data is needed to track the long-term effects of the disease on the hippocampal subfields.
BACKGROUND: NIH R56AG074467, R01MH111265 and R01AG063525 References: 1. Berron et al. Neuroimage 2017 2. Yushkevich et al. Human Brain Mapping 2015 3. Santini et al. Neuroimage: clinical 2021.
方法:我们使用位于两个国家的三个地点的7T扫描仪获得了高分辨率T1加权(T1w)和T2加权(T2w)MRI图像:美国的匹兹堡(n=14)和德克萨斯州(圣安东尼奥和休斯顿)(n=40)。还有诺丁汉,英国(n=33)。我们使用ASHS软件包[1-3]评估了海马子场。分析中包括51个具有最小或没有手动分割校正的受试者的成像集(图1和图2)。我们用Bonferroni校正进行了T检验,调整年龄和颅内体积,以确定各组海马亚区体积的差异。
结果:与不需要ICU的参与者相比,因新冠肺炎而需要进入ICU的参与者显示出显著较低的左CA1体积(p值=0.0034)(图3)。此外,观察到其他几个非显著趋势.
结论:我们的初步研究结果表明,新冠肺炎可能会影响海马,特别是需要重症监护的患者。然而,到目前为止,这项研究的样本量很小,缺乏因新冠肺炎以外的急性疾病而进入ICU的患者的对照组。此外,需要纵向数据来追踪疾病对海马亚区的长期影响.
背景:NIHR56AG074467,R01MH111265和R01AG063525参考文献:1。Berron等人。神经影像2017年2。Yushkevich等人。2015年人脑图3。Santini等人。神经影像:临床2021年。