Abstract：
Aldolase enzymes, particularly ALDOA, ALDOB, and ALDOC, play a crucial role in the development and progression of cancer. While the aldolase family is mainly known for its involvement in the glycolysis pathway, these enzymes also have various pathological and physiological functions through distinct signaling pathways such as Wnt/β-catenin, EGFR/MAPK, Akt, and HIF-1α. This has garnered increased attention in recent years and shed light on other sides of this enzyme. Potential therapeutic strategies targeting aldolases include using siRNA, inhibitors like naphthol AS-E phosphate and TX-2098, and natural compounds such as HDPS-4II and L-carnosine. Additionally, anticancer peptides derived from ALDOA, like P04, can potentially increase cancer cells\' sensitivity to chemotherapy. Aldolases also affect cancer drug resistance by different approaches, making them good therapeutic targets. In this review, we extensively explore the role of aldolase enzymes in various types of cancers in proliferation, invasion, migration, and drug resistance; we also significantly explore the possible treatment considering aldolase function.
摘要：
醛缩酶,特别是ALDOA，ALDOB,和ALDOC,在癌症的发展和进展中起着至关重要的作用。虽然醛缩酶家族主要以参与糖酵解途径而闻名，这些酶还通过不同的信号通路，如Wnt/β-catenin，EGFR/MAPK,Akt,和HIF-1α。近年来，这引起了越来越多的关注，并揭示了这种酶的其他方面。靶向醛缩酶的潜在治疗策略包括使用siRNA，抑制剂如萘酚AS-E磷酸酯和TX-2098，以及天然化合物如HDPS-4II和L-肌肽。此外,来自ALDOA的抗癌肽，像P04一样，可能会增加癌细胞对化疗的敏感性。醛缩酶还通过不同的方法影响癌症的耐药性，使它们成为良好的治疗目标。在这次审查中,我们广泛探索醛缩酶在各种癌症增殖中的作用，入侵,迁移,和耐药性；我们还显着探索考虑醛缩酶功能的可能治疗方法。
