Abstract：
This study aimed to assess the association between composite indices of femoral neck strength and the odds of hip fracture in Chinese adults.After adjusting for confounders, higher values of CSI and ISI were associated with a lower risk of fracture. They may provide useful information for improving hip fracture risk assessment.
OBJECTIVE: With the increased incidence of hip fractures worldwide, numerous studies have reported that composite indices of femoral neck strength can improve hip fracture risk assessment. This study aimed to assess the association between composite indices of femoral neck strength and the odds of hip fracture in Chinese adults.
METHODS: This retrospective cross-sectional study conducted at Changzhou Second People\'s Hospital included 937 Chinese adults (248 with hip fractures). After overnight fasting for ≥ 8 h, blood samples were collected from all participants within 24 h of admission. Composite indices of femoral neck strength were derived by combining bone mineral density, weight, and height with femoral axis length and width, which were measured by dual-energy X-ray absorptiometry.
RESULTS: In total, 937 participants (293 men and 644 women) were enrolled. The mean age was 68.3 years (SD 10.5). After adjusting for confounders, higher values of CSI and ISI were associated with a lower odd of hip fracture. Increase in CSI (per 1 g/m·kg) was associated with a 46% decrease in the odd of hip fracture (OR = 0.54; 95% CI, 0.39-0.74), and increase in ISI (per 0.1 g/m·kg) was associated with an 82% decrease (OR, 0.18; 95% CI, 0.11-0.30). Effect sizes of CSI and ISI on the odds of hip fracture remained robust and reliable in subgroup analyses.
CONCLUSIONS: Increased CSI and ISI were associated with a lower odd of hip fracture, especially in women, suggesting that composite indices of femoral neck strength may provide useful information for improving hip fracture risk assessment.
OBJECTIVE: With the increased incidence of hip fractures worldwide, numerous studies have reported that composite indices of femoral neck strength can improve hip fracture risk assessment. This study aimed to assess the association between composite indices of femoral neck strength and the odds of hip fracture in Chinese adults.
METHODS: This retrospective cross-sectional study conducted at Changzhou Second People\'s Hospital included 937 Chinese adults (248 with hip fractures). After overnight fasting for ≥ 8 h, blood samples were collected from all participants within 24 h of admission. Composite indices of femoral neck strength were derived by combining bone mineral density, weight, and height with femoral axis length and width, which were measured by dual-energy X-ray absorptiometry.
RESULTS: In total, 937 participants (293 men and 644 women) were enrolled. The mean age was 68.3 years (SD 10.5). After adjusting for confounders, higher values of CSI and ISI were associated with a lower odd of hip fracture. Increase in CSI (per 1 g/m·kg) was associated with a 46% decrease in the odd of hip fracture (OR = 0.54; 95% CI, 0.39-0.74), and increase in ISI (per 0.1 g/m·kg) was associated with an 82% decrease (OR, 0.18; 95% CI, 0.11-0.30). Effect sizes of CSI and ISI on the odds of hip fracture remained robust and reliable in subgroup analyses.
CONCLUSIONS: Increased CSI and ISI were associated with a lower odd of hip fracture, especially in women, suggesting that composite indices of femoral neck strength may provide useful information for improving hip fracture risk assessment.
摘要：
这项研究旨在评估中国成年人股骨颈强度的综合指标与髋部骨折的几率之间的关系。在调整了混杂因素后，较高的CSI和ISI值与较低的骨折风险相关.它们可能为改善髋部骨折风险评估提供有用的信息。
目的：随着全球髋部骨折发病率的增加，大量研究报道，股骨颈强度的综合指标可以提高髋部骨折风险评估。这项研究旨在评估中国成年人股骨颈强度的综合指标与髋部骨折的几率之间的关系。
方法：这项在常州第二人民医院进行的回顾性横断面研究包括937名中国成年人（248例髋部骨折）。过夜禁食≥8小时后，在所有参与者入院24小时内采集血液样本.通过结合骨密度得出股骨颈强度的综合指标，体重,和高度与股骨轴长度和宽度，通过双能X射线吸收法测量。
结果：总计，937名参与者（293名男性和644名女性）被纳入。平均年龄为68.3岁（SD10.5）。在调整了混杂因素后，较高的CSI和ISI值与较低的髋部骨折奇数相关。CSI（每1g/m·kg）的增加与髋部骨折奇数减少46％相关（OR=0.54；95％CI，0.39-0.74），ISI的增加(每0.1g/m·kg)与82%的减少相关(OR，0.18；95%CI，0.11-0.30）。在亚组分析中，CSI和ISI对髋部骨折几率的影响大小仍然可靠可靠。
结论：增加的CSI和ISI与髋部骨折的低奇数相关，尤其是女性,提示股骨颈强度的综合指标可能为改善髋部骨折风险评估提供有用的信息。
目的：随着全球髋部骨折发病率的增加，大量研究报道，股骨颈强度的综合指标可以提高髋部骨折风险评估。这项研究旨在评估中国成年人股骨颈强度的综合指标与髋部骨折的几率之间的关系。
方法：这项在常州第二人民医院进行的回顾性横断面研究包括937名中国成年人（248例髋部骨折）。过夜禁食≥8小时后，在所有参与者入院24小时内采集血液样本.通过结合骨密度得出股骨颈强度的综合指标，体重,和高度与股骨轴长度和宽度，通过双能X射线吸收法测量。
结果：总计，937名参与者（293名男性和644名女性）被纳入。平均年龄为68.3岁（SD10.5）。在调整了混杂因素后，较高的CSI和ISI值与较低的髋部骨折奇数相关。CSI（每1g/m·kg）的增加与髋部骨折奇数减少46％相关（OR=0.54；95％CI，0.39-0.74），ISI的增加(每0.1g/m·kg)与82%的减少相关(OR，0.18；95%CI，0.11-0.30）。在亚组分析中，CSI和ISI对髋部骨折几率的影响大小仍然可靠可靠。
结论：增加的CSI和ISI与髋部骨折的低奇数相关，尤其是女性,提示股骨颈强度的综合指标可能为改善髋部骨折风险评估提供有用的信息。
