METHODS: Here, we present a novel liquid biopsy method for prostate cancer based on the identification of specific proteins in the extracellular vesicles isolated from the blood of patients with prostate cancer.
RESULTS: We observed that a specific combination of sEV proteins is a sensitive indicator of prostate cancer. Indeed, we found that the number of clusters expressed by specific combinations of either intra-vesicular (STAT3 and CyclinD1) or surface proteins (ERBB3, ALK, and CD81) allowed us to significantly discriminate the patients with prostate cancer from the individuals with hyperplasia.
CONCLUSIONS: This new liquid biopsy method has the potential to improve prostate cancer screening by providing a non-invasive and more accurate diagnostic tool.
方法:这里,我们提出了一种新的前列腺癌液体活检方法,该方法基于从前列腺癌患者血液中分离的细胞外囊泡中的特定蛋白质的鉴定。
结果:我们观察到sEV蛋白的特定组合是前列腺癌的敏感指标。的确,我们发现,通过囊泡内(STAT3和CyclinD1)或表面蛋白(ERBB3,ALK,和CD81)使我们能够显着区分前列腺癌患者和增生患者。
结论:这种新的液体活检方法具有通过提供非侵入性且更准确的诊断工具来改善前列腺癌筛查的潜力。