PDF(Pubmed)
Abstract：
The triadic interplay between sleep, immunity, and cancer represents a growing area of biomedical research with significant clinical implications. This review synthesizes the current knowledge on how sleep influences immune function, the immune system\'s role in cancer dynamics, and the direct connections between sleep patterns and cancer risk. After a comprehensive overview of the interrelationships among these three domains, the mechanisms of sleep in immune function are described, detailing how sleep regulates the immune system, the effects of sleep duration and quality on immune responses, and the underlying molecular and cellular mechanisms. Also, the complex relationship between immunity and cancer is explored, highlighting the immune system\'s role in cancer prevention and progression, immune surveillance, tumor microenvironment, and the implications of immunodeficiency and immune modulation on cancer risk. The direct connections between sleep and cancer are then described, presenting epidemiological evidence linking sleep patterns to cancer risk, biological mechanisms that influence cancer development, and the role of sleep disorders in cancer prognosis. The mediating role of sleep between immunity and cancer is highlighted, proposing hypothesized pathways, summarizing evidence from experimental and clinical studies, and evaluating the impact of sleep interventions on immune function and cancer outcomes. This review concludes by discussing the clinical implications and future directions, emphasizing the potential for sleep-based interventions in cancer prevention and treatment, the integration of sleep management in oncology and immunotherapy, and outlining a future research agenda. This agenda includes understanding the mechanisms of the sleep-immunity-cancer interplay, conducting epidemiological studies on sleep and cancer risk, assessing the impact of sleep management in cancer treatment protocols, exploring sleep and tumor microenvironment interactions, and considering policy and public health implications. Through a detailed examination of these interconnected pathways, this review underscores the critical importance of sleep in modulating immune function and cancer outcomes, advocating for interdisciplinary research and clinical strategies to harness this knowledge for improved health outcomes.
摘要：
睡眠之间的三重相互作用，豁免权,和癌症代表了生物医学研究的一个不断增长的领域，具有重要的临床意义。这篇综述综合了目前关于睡眠如何影响免疫功能的知识，免疫系统在癌症动力学中的作用，以及睡眠模式和癌症风险之间的直接联系。在全面概述了这三个领域之间的相互关系之后，描述了睡眠在免疫功能中的机制，详细说明睡眠如何调节免疫系统，睡眠时间和质量对免疫反应的影响，以及潜在的分子和细胞机制。此外，探讨了免疫与癌症之间的复杂关系，强调免疫系统在癌症预防和进展中的作用，免疫监视,肿瘤微环境,以及免疫缺陷和免疫调节对癌症风险的影响。然后描述了睡眠和癌症之间的直接联系，提供流行病学证据将睡眠模式与癌症风险联系起来，影响癌症发展的生物学机制，以及睡眠障碍在癌症预后中的作用。睡眠在免疫和癌症之间的中介作用被强调，提出假设的途径，总结实验和临床研究的证据，并评估睡眠干预对免疫功能和癌症预后的影响。这篇综述最后讨论了临床意义和未来的方向，强调睡眠干预在癌症预防和治疗中的潜力，肿瘤和免疫治疗的睡眠管理的整合，并概述了未来的研究议程。该议程包括了解睡眠-免疫-癌症相互作用的机制，对睡眠和癌症风险进行流行病学研究，评估睡眠管理对癌症治疗方案的影响，探索睡眠和肿瘤微环境的相互作用，并考虑政策和公共卫生影响。通过对这些相互关联的途径的详细检查，这篇综述强调了睡眠在调节免疫功能和癌症预后方面的重要性，倡导跨学科研究和临床策略，以利用这些知识改善健康结果。
