PDF(Pubmed)
Abstract：
The endometrium is crucial for the perpetuation of human species. It is a complex and dynamic tissue lining the inner wall of the uterus, regulated throughout a woman\'s life based on estrogen and progesterone fluctuations. During each menstrual cycle, this multicellular tissue undergoes cyclical changes, including regeneration, differentiation in order to allow egg implantation and embryo development, or shedding of the functional layer in the absence of pregnancy. The biology of the endometrium relies on paracrine interactions between epithelial and stromal cells involving complex signaling pathways that are modulated by the variations of estrogen and progesterone levels across the menstrual cycle. Understanding the complexity of estrogen and progesterone receptor signaling will help elucidate the mechanisms underlying normal reproductive physiology and provide fundamental knowledge contributing to a better understanding of the consequences of hormonal imbalances on gynecological conditions and tumorigenesis. In this narrative review, we delve into the physiology of the endometrium, encompassing the complex signaling pathways of estrogen and progesterone.
摘要：
子宫内膜对于人类物种的延续至关重要。它是子宫内壁的复杂动态组织，基于雌激素和孕激素的波动调节整个女人的生活。在每个月经周期中，这种多细胞组织经历周期性变化，包括再生，分化以允许卵子植入和胚胎发育，或在没有怀孕的情况下功能层脱落。子宫内膜的生物学依赖于上皮细胞和基质细胞之间的旁分泌相互作用，涉及复杂的信号通路，这些通路受整个月经周期中雌激素和孕激素水平变化的调节。了解雌激素和孕激素受体信号的复杂性将有助于阐明正常生殖生理学的潜在机制，并提供有助于更好地了解激素失衡对妇科疾病和肿瘤发生的后果的基本知识。在这篇叙述性评论中，我们深入研究子宫内膜的生理学，包括雌激素和孕激素的复杂信号通路。
