Mesh : Humans Male Adult Histoplasmosis / drug therapy diagnosis AIDS-Related Opportunistic Infections / drug therapy diagnosis microbiology Histoplasma / isolation & purification Antifungal Agents / therapeutic use administration & dosage HIV Infections / complications drug therapy Amphotericin B / therapeutic use administration & dosage Itraconazole / therapeutic use administration & dosage Immunocompromised Host

来  源:   DOI:10.61409/V03240205

Abstract:
Histoplasmosis capsulatum is a dimorphic fungus, recognised for its endemic presence in multiple global regions. It may cause severe opportunistic disseminated infection in immunocompromised individuals. This is a case report of a 33-year-old man from Thailand who was admitted at a Danish hospital with fever, weight loss, cough, nosebleeds, and newly diagnosed HIV. The clinical condition rapidly deteriorated with lung and kidney failure. The patient was diagnosed with H. capsulatum fungaemia first detected on blood smear. He was treated with intravenous amphotericin B followed by oral itraconazole as well as antiretroviral therapy.
摘要:
荚膜组织胞浆菌病是一种双态真菌,因其在多个全球地区的地方性存在而得到认可。它可能在免疫功能低下的个体中引起严重的机会性播散性感染。这是一名来自泰国的33岁男子因发烧在丹麦医院住院的病例报告,减肥,咳嗽,流鼻血,和新诊断的艾滋病毒。临床病情迅速恶化,并伴有肺和肾衰竭。该患者被诊断为首次在血液涂片上检测到的荚膜H.他接受了静脉注射两性霉素B,然后口服伊曲康唑以及抗逆转录病毒治疗。
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