Abstract：
BACKGROUND: Obesity and diabetes are associated with altered gastrointestinal function and with the development of abdominal pain, nausea, diarrhea, and constipation among other symptoms. The enteric nervous system (ENS) regulates gastrointestinal motility. Enteric neuropathies defined as damage or loss of enteric neurons can lead to motility disorders.
OBJECTIVE: Here, we review the molecular mechanisms that drive enteric neurodegeneration in diabetes and obesity, including signaling pathways leading to neuronal cell death, oxidative stress, and microbiota alteration. We also highlight potential approaches to treat enteric neuropathies including antioxidant therapy to prevent oxidative stress-induced damage and the use of stem cells.
OBJECTIVE: Here, we review the molecular mechanisms that drive enteric neurodegeneration in diabetes and obesity, including signaling pathways leading to neuronal cell death, oxidative stress, and microbiota alteration. We also highlight potential approaches to treat enteric neuropathies including antioxidant therapy to prevent oxidative stress-induced damage and the use of stem cells.
摘要：
背景：肥胖和糖尿病与胃肠功能改变和腹痛的发展有关，恶心,腹泻,和便秘等症状。肠神经系统(ENS)调节胃肠蠕动。定义为肠神经元的损伤或损失的肠神经病可导致运动性障碍。
目标：这里，我们回顾了在糖尿病和肥胖症中驱动肠神经变性的分子机制，包括导致神经元细胞死亡的信号通路，氧化应激，和微生物群的改变。我们还强调了治疗肠神经病的潜在方法，包括抗氧化疗法以防止氧化应激诱导的损伤和使用干细胞。
目标：这里，我们回顾了在糖尿病和肥胖症中驱动肠神经变性的分子机制，包括导致神经元细胞死亡的信号通路，氧化应激，和微生物群的改变。我们还强调了治疗肠神经病的潜在方法，包括抗氧化疗法以防止氧化应激诱导的损伤和使用干细胞。
