OBJECTIVE: Here, we review the molecular mechanisms that drive enteric neurodegeneration in diabetes and obesity, including signaling pathways leading to neuronal cell death, oxidative stress, and microbiota alteration. We also highlight potential approaches to treat enteric neuropathies including antioxidant therapy to prevent oxidative stress-induced damage and the use of stem cells.
目标:这里,我们回顾了在糖尿病和肥胖症中驱动肠神经变性的分子机制,包括导致神经元细胞死亡的信号通路,氧化应激,和微生物群的改变。我们还强调了治疗肠神经病的潜在方法,包括抗氧化疗法以防止氧化应激诱导的损伤和使用干细胞。