PDF(Pubmed)
Abstract：
Multiwalled carbon nanotubes (MWCNTs) are at the forefront of nanotechnology-based advancements in cancer therapy, particularly in the field of targeted drug delivery. The nanotubes are characterized by their concentric graphene layers, which give them outstanding structural strength. They can deliver substantial doses of therapeutic agents, potentially reducing treatment frequency and improving patient compliance. MWCNTs\' diminutive size and modifiable surface enable them to have a high drug loading capacity and penetrate biological barriers. As a result of the extensive research on these nanomaterials, they have been studied extensively as synthetic and chemically functionalized molecules, which can be combined with various ligands (such as folic acid, antibodies, peptides, mannose, galactose, polymers) and linkers, and to deliver anticancer drugs, including but not limited to paclitaxel, docetaxel, cisplatin, doxorubicin, tamoxifen, methotrexate, quercetin and others, to cancer cells. This functionalization facilitates selective targeting of cancer cells, as these ligands bind to specific receptors overexpressed in tumor cells. By sparing non-cancerous cells and delivering the therapeutic payload precisely to cancer cells, this therapeutic payload delivery ability reduces chemotherapy systemic toxicity. There is great potential for MWCNTs to be used as targeted delivery systems for drugs. In this review, we discuss techniques for functionalizing and conjugating MWCNTs to drugs using natural and biomacromolecular linkers, which can bind to the cancer cells\' receptors/biomolecules. Using MWCNTs to administer cancer drugs is a transformative approach to cancer treatment that combines nanotechnology and pharmacotherapy. It is an exciting and rich field of research to explore and optimize MWCNTs for drug delivery purposes, which could result in significant benefits for cancer patients.
摘要：
多壁碳纳米管（MWCNT）是基于纳米技术的癌症治疗进展的前沿，特别是在靶向药物递送领域。纳米管的特征在于它们的同心石墨烯层，这给了他们突出的结构强度。它们可以提供大量的治疗剂，可能减少治疗频率并提高患者依从性。MWCNTs的小尺寸和可修饰的表面使它们具有高的药物负载能力并穿透生物屏障。由于对这些纳米材料的广泛研究，它们作为合成和化学官能化的分子被广泛研究，它可以与各种配体(如叶酸，抗体，肽，甘露糖,半乳糖,聚合物)和连接体，并提供抗癌药物，包括但不限于紫杉醇，多西他赛,顺铂,阿霉素,他莫昔芬,甲氨蝶呤,槲皮素和其他,癌细胞。这种功能化促进了癌细胞的选择性靶向，因为这些配体与肿瘤细胞中过表达的特异性受体结合。通过保留非癌细胞并将治疗有效载荷精确地传递给癌细胞，这种治疗有效负载递送能力降低了化疗的全身毒性。MWCNT用作药物的靶向递送系统具有很大的潜力。在这次审查中,我们讨论了使用天然和生物大分子接头将MWCNT功能化和缀合到药物上的技术，可以与癌细胞受体/生物分子结合。使用MWCNT管理癌症药物是结合纳米技术和药物治疗的癌症治疗的变革性方法。探索和优化用于药物递送目的的MWCNT是一个令人兴奋和丰富的研究领域，这可能会给癌症患者带来巨大的好处。
