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Abstract：
Long noncoding RNAs (lncRNAs) constitute a distinctive subset of RNA molecules with limited protein-coding potential, which exert crucial impacts on various biological activities. In the context of cancer, dysregulated lncRNAs function as essential regulators that affect tumor initiation and malignant progression. These lncRNAs serve as competitive endogenous RNAs (ceRNAs) through sponging microRNAs and regulating the expression of targeted genes. Moreover, they also directly bind to RNA-binding proteins, which can be integrated into a complex mechanistic network. E2F1, an extensively studied transcription factor, mediates multiple malignant behaviors by regulating cell cycle progression, tumor metastasis, and therapeutic response. Emerging evidence suggests that lncRNAs play a pivotal role in regulating the E2F1 pathway. This review aims to elucidate the intricate gene regulatory programs between lncRNAs and E2F1 in cancer progression. We elaborate on distinct mechanistic networks involved in cancer progression, emphasizing the potential of the lncRNAs/E2F1 axes as promising targets for cancer therapy. Additionally, we provide novel perspectives on current evidence, limitations, and future directions for targeting lncRNAs in human cancers. Fully deciphering the intricate network of lncRNA/E2F1-mediated regulatory mechanisms in cancer could facilitate the translation of current findings into clinical course, such efforts ultimately significantly improve the clinical prognosis of cancer patients.
摘要：
长链非编码RNA（lncRNAs）构成了一个独特的蛋白质编码潜力有限的RNA分子子集，对各种生物活动产生至关重要的影响。在癌症的背景下，失调的lncRNAs作为影响肿瘤发生和恶性进展的必需调节因子发挥作用。这些lncRNA通过形成微小RNA并调节靶基因的表达而充当竞争性内源性RNA(ceRNA)。此外，它们还直接与RNA结合蛋白结合，可以集成到一个复杂的机械网络中。E2F1，广泛研究的转录因子，通过调节细胞周期进程介导多种恶性行为，肿瘤转移，和治疗反应。新出现的证据表明lncRNAs在调节E2F1通路中起关键作用。这篇综述旨在阐明lncRNAs和E2F1在癌症进展中的复杂基因调控程序。我们详细阐述了参与癌症进展的不同机制网络，强调lncRNAs/E2F1轴作为癌症治疗有希望的靶标的潜力。此外,我们对当前的证据提供了新颖的观点，局限性,以及在人类癌症中靶向lncRNAs的未来方向。完全破译lncRNA/E2F1介导的癌症调节机制的复杂网络可以促进将当前发现转化为临床过程。这些努力最终显著改善癌症患者的临床预后。
