PDF(Pubmed)
Abstract：
UNASSIGNED: The bulbs of Allium sativum are widely used as food or seasoning (garlic), while they have also been utilized as a famous traditional medicine since ancient eras for the treatment of scabies, tuberculosis, pertussis, diarrhea and dysentery, etc. However, very few studies focus on their abundant aerial parts, which are normally discarded during the harvest season.
UNASSIGNED: The hyperlipidemic mice model has been used to study the lipid-lowering effect of the aerial parts in this article. 180 mice were randomly divided into 18 groups, including blank control (BC), model (Mod), positive control (PC), and low-, medium-, and high-dose groups of the crude extract, petroleum ether, ethyl acetate, n-butanol, and residual water extracts (corresponding to CE, PEE, EAE, NBE, WE), with 10 mice in each group. The preventive effects of the extracts on hyperlipidemic mice lasted for four weeks. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) were used to analyze the chemical components of NBE and PEE respectively.
UNASSIGNED: The results of the mice experiment showed that n-butanol extract (NBE) and petroleum ether extract (PEE) from the aerial parts could significantly reduce the contents of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT) and aspartate transaminase (AST) in serum of hyperlipidemic mice, and increase the contents of high density lipoprotein cholesterol (HDL-C). They could enhance the activity of superoxide dismutase (SOD) in liver and reduce the level of malondialdehyde (MDA). At the same time, they could improve steatosis and inflammation of liver cells. The results of phytochemical components analysis showed that NBE was rich in organic acids, flavonoids and nitrogen-containing constituents, while PEE contained organic sulfur compounds, aliphatic acids and derivatives, alkaloids, phytosterols, etc.
UNASSIGNED: These results support that the aerial parts of A. sativum are an interesting source of bioactive ingredients that may be useful in the prevention and treatment of hyperlipidemia.
UNASSIGNED: The hyperlipidemic mice model has been used to study the lipid-lowering effect of the aerial parts in this article. 180 mice were randomly divided into 18 groups, including blank control (BC), model (Mod), positive control (PC), and low-, medium-, and high-dose groups of the crude extract, petroleum ether, ethyl acetate, n-butanol, and residual water extracts (corresponding to CE, PEE, EAE, NBE, WE), with 10 mice in each group. The preventive effects of the extracts on hyperlipidemic mice lasted for four weeks. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) were used to analyze the chemical components of NBE and PEE respectively.
UNASSIGNED: The results of the mice experiment showed that n-butanol extract (NBE) and petroleum ether extract (PEE) from the aerial parts could significantly reduce the contents of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT) and aspartate transaminase (AST) in serum of hyperlipidemic mice, and increase the contents of high density lipoprotein cholesterol (HDL-C). They could enhance the activity of superoxide dismutase (SOD) in liver and reduce the level of malondialdehyde (MDA). At the same time, they could improve steatosis and inflammation of liver cells. The results of phytochemical components analysis showed that NBE was rich in organic acids, flavonoids and nitrogen-containing constituents, while PEE contained organic sulfur compounds, aliphatic acids and derivatives, alkaloids, phytosterols, etc.
UNASSIGNED: These results support that the aerial parts of A. sativum are an interesting source of bioactive ingredients that may be useful in the prevention and treatment of hyperlipidemia.
摘要：
■葱的鳞茎被广泛用作食物或调味料（大蒜），虽然它们自古以来也被用作治疗c疮的著名传统医学，结核病,百日咳,腹泻和痢疾,等。然而,很少有研究关注它们丰富的空中部分，通常在收获季节丢弃。
■高脂血症小鼠模型已用于研究本文中的地上部分的降脂作用。180只小鼠随机分为18组,包括空白对照(BC)，模型（Mod），阳性对照（PC），和低，medium-,和粗提取物的高剂量组，石油醚,乙酸乙酯,正丁醇,和残留的水提取物(对应于CE，PEE,EAE,NBE,WE),每组10只小鼠。提取物对高脂血症小鼠的预防作用持续4周。采用超高效液相色谱-四极杆飞行时间质谱(UPLC-Q/TOF-MS)和气相色谱-串联质谱(GC-MS/MS)分别对NBE和PEE的化学成分进行分析。
■小鼠实验结果表明，地上部分的正丁醇提取物（NBE）和石油醚提取物（PEE）可以显着降低总胆固醇（TC）的含量，甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C），高血脂小鼠血清丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST),并增加高密度脂蛋白胆固醇（HDL-C）的含量。它们可以增强肝脏中超氧化物歧化酶（SOD）的活性，降低丙二醛（MDA）的水平。同时,它们可以改善肝细胞的脂肪变性和炎症。植物化学成分分析结果表明,NBE中含有丰富的有机酸,类黄酮和含氮成分，虽然PEE含有有机硫化合物，脂肪酸和衍生物，生物碱，植物甾醇，等。
■这些结果支持A的地上部分是可能用于预防和治疗高脂血症的生物活性成分的有趣来源。
■高脂血症小鼠模型已用于研究本文中的地上部分的降脂作用。180只小鼠随机分为18组,包括空白对照(BC)，模型（Mod），阳性对照（PC），和低，medium-,和粗提取物的高剂量组，石油醚,乙酸乙酯,正丁醇,和残留的水提取物(对应于CE，PEE,EAE,NBE,WE),每组10只小鼠。提取物对高脂血症小鼠的预防作用持续4周。采用超高效液相色谱-四极杆飞行时间质谱(UPLC-Q/TOF-MS)和气相色谱-串联质谱(GC-MS/MS)分别对NBE和PEE的化学成分进行分析。
■小鼠实验结果表明，地上部分的正丁醇提取物（NBE）和石油醚提取物（PEE）可以显着降低总胆固醇（TC）的含量，甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C），高血脂小鼠血清丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST),并增加高密度脂蛋白胆固醇（HDL-C）的含量。它们可以增强肝脏中超氧化物歧化酶（SOD）的活性，降低丙二醛（MDA）的水平。同时,它们可以改善肝细胞的脂肪变性和炎症。植物化学成分分析结果表明,NBE中含有丰富的有机酸,类黄酮和含氮成分，虽然PEE含有有机硫化合物，脂肪酸和衍生物，生物碱，植物甾醇，等。
■这些结果支持A的地上部分是可能用于预防和治疗高脂血症的生物活性成分的有趣来源。
