PDF(Pubmed)
Abstract：
Insulin autoimmune syndrome (IAS) is characterized by spontaneous hyperinsulinemic hypoglycemia and the presence of insulin autoantibodies in high titers without exogenous insulin use. The C-peptide level during a hypoglycemia episode is useful for differentiating spontaneous hypoglycemia. Generally, low C-peptides are suspicious for exogenous insulin administration. We report a 47-year-old male nurse who presented with an initial episode of hypoglycemia. Despite the pattern of hyperinsulinemic hypoglycemia and low C-peptide, he was diagnosed with IAS based on the presence of insulin autoantibodies. This case underscores the importance of suspecting IAS in non-diabetic adults with hypoglycemia, even in the setting of low C-peptide levels.
摘要：
胰岛素自身免疫综合征（IAS）的特征是自发性高胰岛素血症性低血糖和高滴度胰岛素自身抗体的存在，而无需使用外源性胰岛素。低血糖发作期间的C肽水平可用于区分自发性低血糖。一般来说,低C肽对于外源性胰岛素给药是可疑的。我们报告了一名47岁的男护士，他最初出现了低血糖。尽管高胰岛素血症性低血糖和低C肽的模式，根据胰岛素自身抗体的存在,他被诊断为IAS.该病例强调了在患有低血糖的非糖尿病成人中怀疑IAS的重要性。即使在低C肽水平的情况下。
