PDF(Pubmed)
Abstract：
Metastatic melanoma presents a significant clinical challenge, characterized by its aggressive nature and propensity to spread to multiple organ systems. Despite advances in detection and treatment, managing metastatic disease remains complex. Here, we present the case of a 43-year-old male with metastatic melanoma displaying an unusual pattern of involvement, affecting the adrenal gland, liver, spleen, and bones. The diagnostic process was intricate, involving atypical hormonal profiles and a negative BRAF status, necessitating a comprehensive approach for accurate characterization and treatment selection. Immunotherapy demonstrated efficacy but also highlighted the emergence of immune-related adverse events, notably hyperglycemia. This case discusses the heterogeneous nature of metastatic melanoma and underscores the importance of a multidisciplinary approach, close monitoring, and consideration of evolving treatment strategies in its management.
摘要：
转移性黑色素瘤提出了重大的临床挑战，以其侵袭性和扩散到多个器官系统的倾向为特征。尽管在检测和治疗方面取得了进展，转移性疾病的管理仍然很复杂.这里,我们介绍了一个43岁男性转移性黑色素瘤的病例，表现出异常的受累模式，影响肾上腺，肝脏,脾,脾和骨头。诊断过程错综复杂,涉及非典型的荷尔蒙概况和阴性的BRAF状态，需要一种全面的方法来进行准确的表征和治疗选择。免疫治疗显示出疗效，但也突出了免疫相关不良事件的出现，尤其是高血糖症。这个案例讨论了转移性黑色素瘤的异质性，并强调了多学科方法的重要性。密切监测,并在管理中考虑不断发展的治疗策略。
