PDF(Pubmed)
Abstract：
UNASSIGNED: Previous observational studies have revealed the strong relationship between fatty acids (FA) and inflammatory bowel disease (IBD). Nonetheless, due to the inherent limitations of retrospective research, the causality between the two has not been clearly established.
UNASSIGNED: Genetic variants associated with the 17 FA indicators were derived from genome-wide association studies. Summary statistics for the discovery cohort and testing cohort for IBD, including ulcerative colitis (UC) and Crohn\'s disease (CD), were available from IIBDGC and FinnGen, respectively. Bidirectional MR analysis and sensitivity analysis with multiple measures were applied to comprehensively investigate the causal link between FA and IBD.
UNASSIGNED: Combining the results of various MR methods, the validation of testing cohort, and the merging of meta-analysis, we demonstrated that genetically predicted Omega-3 FA levels, Ratio of Omega-3 FA to total FA, Docosahexaenoic acid (DHA) levels, and Ratio of DHA to total FA reduced the risk of IBD, UC, and CD. Meanwhile, multivariate MR suggested that the risk effects of Omega-3 FA and DHA for UC and CD were mainly affected by Saturated FA and Monounsaturated fatty acid (MUFA). Furthermore, although there was the causal association between Ratio of MUFA to total FA as well as Ratio of Polyunsaturated fatty acid (PUFA) to MUFA and CD, sensitivity analysis prompted that the findings were not robust. None of the above results had a reverse causal effect.
UNASSIGNED: This MR investigation provided evidence of causality between diverse FA and IBD. These findings offered new insights into the treatment and prevention of IBD.
UNASSIGNED: Genetic variants associated with the 17 FA indicators were derived from genome-wide association studies. Summary statistics for the discovery cohort and testing cohort for IBD, including ulcerative colitis (UC) and Crohn\'s disease (CD), were available from IIBDGC and FinnGen, respectively. Bidirectional MR analysis and sensitivity analysis with multiple measures were applied to comprehensively investigate the causal link between FA and IBD.
UNASSIGNED: Combining the results of various MR methods, the validation of testing cohort, and the merging of meta-analysis, we demonstrated that genetically predicted Omega-3 FA levels, Ratio of Omega-3 FA to total FA, Docosahexaenoic acid (DHA) levels, and Ratio of DHA to total FA reduced the risk of IBD, UC, and CD. Meanwhile, multivariate MR suggested that the risk effects of Omega-3 FA and DHA for UC and CD were mainly affected by Saturated FA and Monounsaturated fatty acid (MUFA). Furthermore, although there was the causal association between Ratio of MUFA to total FA as well as Ratio of Polyunsaturated fatty acid (PUFA) to MUFA and CD, sensitivity analysis prompted that the findings were not robust. None of the above results had a reverse causal effect.
UNASSIGNED: This MR investigation provided evidence of causality between diverse FA and IBD. These findings offered new insights into the treatment and prevention of IBD.
摘要：
■先前的观察性研究揭示了脂肪酸（FA）与炎症性肠病（IBD）之间的密切关系。尽管如此，由于回顾性研究的固有局限性，两者之间的因果关系尚未明确。
■与17个FA指标相关的遗传变异来自全基因组关联研究。IBD的发现队列和测试队列的汇总统计，包括溃疡性结肠炎（UC）和克罗恩病（CD），可以从IIBDGC和FinnGen获得，分别。应用双向MR分析和多种测量的敏感性分析来全面研究FA和IBD之间的因果关系。
■结合各种MR方法的结果，测试队列的验证，和荟萃分析的合并，我们证明了基因预测的Omega-3FA水平，Omega-3FA与总FA的比率，二十二碳六烯酸（DHA）水平，DHA与总FA的比率降低了IBD的风险，UC,和CD。同时,多变量MR提示Omega-3FA和DHA对UC和CD的风险影响主要受饱和FA和单不饱和脂肪酸（MUFA）的影响。此外，尽管MUFA与总FA的比率以及多不饱和脂肪酸（PUFA）与MUFA和CD的比率之间存在因果关系，敏感性分析提示研究结果并不稳健.上述结果均无反向因果效应。
■这项MR调查提供了不同FA和IBD之间因果关系的证据。这些发现为IBD的治疗和预防提供了新的见解。
■与17个FA指标相关的遗传变异来自全基因组关联研究。IBD的发现队列和测试队列的汇总统计，包括溃疡性结肠炎（UC）和克罗恩病（CD），可以从IIBDGC和FinnGen获得，分别。应用双向MR分析和多种测量的敏感性分析来全面研究FA和IBD之间的因果关系。
■结合各种MR方法的结果，测试队列的验证，和荟萃分析的合并，我们证明了基因预测的Omega-3FA水平，Omega-3FA与总FA的比率，二十二碳六烯酸（DHA）水平，DHA与总FA的比率降低了IBD的风险，UC,和CD。同时,多变量MR提示Omega-3FA和DHA对UC和CD的风险影响主要受饱和FA和单不饱和脂肪酸（MUFA）的影响。此外，尽管MUFA与总FA的比率以及多不饱和脂肪酸（PUFA）与MUFA和CD的比率之间存在因果关系，敏感性分析提示研究结果并不稳健.上述结果均无反向因果效应。
■这项MR调查提供了不同FA和IBD之间因果关系的证据。这些发现为IBD的治疗和预防提供了新的见解。
