UNASSIGNED: The two cases described involve twin brothers, both presenting with respiratory tract infections and renal manifestations. Subsequent genetic testing confirmed the diagnosis of XLA. The younger brother exhibited improvement following intravenous immunoglobulin (IVIG) therapy and anti-infection treatment. Due to financial constraints, the older brother received only anti-infection and symptomatic treatments. Seven months after discharge, the older brother developed nephritis. However, he showed improvement following IVIG treatment.
UNASSIGNED: Immune profiling and genetic testing should be considered in male children with recurrent infections to facilitate the effective diagnosis of XLA. Regular monitoring is also imperative to detect and treat immune-mediated renal diseases in patients with XLA.
■所描述的两个案例涉及孪生兄弟,均表现为呼吸道感染和肾脏表现。随后的基因检测证实了XLA的诊断。弟弟在静脉注射免疫球蛋白(IVIG)治疗和抗感染治疗后表现出改善。由于资金紧张,哥哥只接受了抗感染和对症治疗。出院后七个月,哥哥患上了肾炎。然而,他在IVIG治疗后表现出改善。
■对于复发性感染的男性儿童,应考虑进行免疫分析和基因检测,以促进XLA的有效诊断。定期监测对于检测和治疗XLA患者的免疫介导的肾脏疾病也是必要的。