PDF(Pubmed)
Abstract：
UNASSIGNED: Xeroderma pigmentosum (XP) is a rare inherited disorder with a high incidence of malignant tumours. Literature data on dermoscopic and in vivo reflectance confocal microscopy (RCM) findings in patients with XP are very limited.
UNASSIGNED: Dermoscopic findings in 32 biopsy-proven BCCs and RCM findings in 10 biopsy-proven BCCs developed in seven XP patients were reviewed.
UNASSIGNED: Of 32 BCCs, 28 were pigmented. On dermoscopy, BCCs exhibited multiple grey-blue globules/dots (81, 3%), short-fine telangiectasias/fine arborising vessels (65, 6%), multiple grey-blue ovoid nests (53, 1%), white structures (white-red structureless areas/shiny white areas/lines/strands) (56, 3%), arborising vessels (37, 5%), brown nests/globules/dots (28, 1%), spoke-wheel structures (9, 4%), leaf-like areas (9, 4%), ulceration (28, 1%), peripheral network (21, 9%), and multiple aggregated yellow-white globules (3, 1%). In 10 lesions in which further imaging with RCM was performed, RCM findings differentiated BCC from other tumours, including primary melanoma.
UNASSIGNED: Although the dominancy of pigmented structures may imitate melanoma clinically, dermoscopy is a valuable tool in the early diagnosis of BCCs in patients with XP. For suspicious lesions, RCM can help in differentiating pigmented BCC from primary melanoma.
UNASSIGNED: Dermoscopic findings in 32 biopsy-proven BCCs and RCM findings in 10 biopsy-proven BCCs developed in seven XP patients were reviewed.
UNASSIGNED: Of 32 BCCs, 28 were pigmented. On dermoscopy, BCCs exhibited multiple grey-blue globules/dots (81, 3%), short-fine telangiectasias/fine arborising vessels (65, 6%), multiple grey-blue ovoid nests (53, 1%), white structures (white-red structureless areas/shiny white areas/lines/strands) (56, 3%), arborising vessels (37, 5%), brown nests/globules/dots (28, 1%), spoke-wheel structures (9, 4%), leaf-like areas (9, 4%), ulceration (28, 1%), peripheral network (21, 9%), and multiple aggregated yellow-white globules (3, 1%). In 10 lesions in which further imaging with RCM was performed, RCM findings differentiated BCC from other tumours, including primary melanoma.
UNASSIGNED: Although the dominancy of pigmented structures may imitate melanoma clinically, dermoscopy is a valuable tool in the early diagnosis of BCCs in patients with XP. For suspicious lesions, RCM can help in differentiating pigmented BCC from primary melanoma.
摘要：
■着色性干皮病（XP）是一种罕见的遗传性疾病，恶性肿瘤的发病率很高。关于XP患者的皮肤镜和体内反射共聚焦显微镜（RCM）发现的文献数据非常有限。
■对7例XP患者中32例活检证实的BCC的皮肤镜检查结果和10例活检证实的BCC的RCM结果进行了回顾。
■在32个BCC中，28人有色素。在皮肤镜上，BCC表现出多个灰蓝色小球/点（81，3％），短细毛细血管扩张/细血管（65，6％），多个灰蓝色卵形巢（53，1%），白色结构（白色-红色无结构区域/闪亮的白色区域/线/线）（56，3%），树胶船(37%，5%)，棕色巢/球/点（28，1%），轮辐结构(9%，4%)，叶状面积（9%，4%），溃疡（28，1%），外围网络（21，9%），和多个聚集的黄白色小球(3,1%)。在进行了RCM进一步成像的10个病变中，RCM发现将BCC与其他肿瘤区分开来，包括原发性黑色素瘤.
■尽管色素结构的优势可能在临床上模仿黑色素瘤，皮肤镜检查是XP患者早期诊断BCCs的有价值的工具。对于可疑病变，RCM可以帮助区分色素性BCC与原发性黑色素瘤。
■对7例XP患者中32例活检证实的BCC的皮肤镜检查结果和10例活检证实的BCC的RCM结果进行了回顾。
■在32个BCC中，28人有色素。在皮肤镜上，BCC表现出多个灰蓝色小球/点（81，3％），短细毛细血管扩张/细血管（65，6％），多个灰蓝色卵形巢（53，1%），白色结构（白色-红色无结构区域/闪亮的白色区域/线/线）（56，3%），树胶船(37%，5%)，棕色巢/球/点（28，1%），轮辐结构(9%，4%)，叶状面积（9%，4%），溃疡（28，1%），外围网络（21，9%），和多个聚集的黄白色小球(3,1%)。在进行了RCM进一步成像的10个病变中，RCM发现将BCC与其他肿瘤区分开来，包括原发性黑色素瘤.
■尽管色素结构的优势可能在临床上模仿黑色素瘤，皮肤镜检查是XP患者早期诊断BCCs的有价值的工具。对于可疑病变，RCM可以帮助区分色素性BCC与原发性黑色素瘤。
