PDF(Pubmed)
Abstract：
UNASSIGNED: Lymph node ratio (LNR) and number of pathological positive nodes (pN) have shown better prognostic prediction compared to laterality, size and number of nodes (single or multiple). This study evaluates the prognostic significance of LNR and the number of pathological positive nodes in predicting the outcomes of node positive oral squamous cell carcinoma(OSCC). It attempts to assess the prognostic heterogeneity between oral tongue and gingivobuccal complex tumours based on the lymph node ratio and the number of pathological positive nodes.
UNASSIGNED: A retrospective chart review of 498 previously untreated OSCC patients from January 2014 to December 2017 at our tertiary cancer institute was done. Our analysis included 133 oral tongue and 79 gingivobuccal tumours with histopathologically proven lymph node metastasis. The impact of LNR and number of positive nodes on overall survival and disease free survival was studied.
UNASSIGNED: Overall survival rate was found to vary significantly based on LNR (> 0.06) and number of positive nodes (> 2). Overall survival reduced significantly in GBC tumours when LNR was more than 0.06(63.37 vs 32.1, p 0.005) but the same trend was not seen with tongue cancers (55.61 vs 41.9, p 0.98). Both the groups shown no difference in DFS based on LNR. Overall survival reduced significantly in both the groups when >2o pathologically positive nodes were present but disease free survival did not vary significantly in both the groups.
UNASSIGNED: Lymph node ratio (> 0.06) and number of pathological positive nodes (> 2) provide a better prognostic stratification in node positive oral squamous cell carcinoma. Oral tongue and GBC tumours were found to have a differential impact on overall survival rate on the stratification based on LNR.
UNASSIGNED: A retrospective chart review of 498 previously untreated OSCC patients from January 2014 to December 2017 at our tertiary cancer institute was done. Our analysis included 133 oral tongue and 79 gingivobuccal tumours with histopathologically proven lymph node metastasis. The impact of LNR and number of positive nodes on overall survival and disease free survival was studied.
UNASSIGNED: Overall survival rate was found to vary significantly based on LNR (> 0.06) and number of positive nodes (> 2). Overall survival reduced significantly in GBC tumours when LNR was more than 0.06(63.37 vs 32.1, p 0.005) but the same trend was not seen with tongue cancers (55.61 vs 41.9, p 0.98). Both the groups shown no difference in DFS based on LNR. Overall survival reduced significantly in both the groups when >2o pathologically positive nodes were present but disease free survival did not vary significantly in both the groups.
UNASSIGNED: Lymph node ratio (> 0.06) and number of pathological positive nodes (> 2) provide a better prognostic stratification in node positive oral squamous cell carcinoma. Oral tongue and GBC tumours were found to have a differential impact on overall survival rate on the stratification based on LNR.
摘要：
■与侧向相比，淋巴结比率（LNR）和病理阳性淋巴结数（pN）显示出更好的预后预测，节点的大小和数量（单个或多个）。这项研究评估了LNR和病理阳性淋巴结数量在预测淋巴结阳性口腔鳞状细胞癌（OSCC）预后中的意义。它试图根据淋巴结比率和病理阳性淋巴结的数量来评估口腔舌和牙龈颊复杂肿瘤之间的预后异质性。
对2014年1月至2017年12月在我们三级癌症研究所进行的498名以前未经治疗的OSCC患者进行了回顾性图表回顾。我们的分析包括133例经组织病理学证实有淋巴结转移的口腔舌和79例牙龈颊肿瘤。研究了LNR和阳性淋巴结数对总生存期和无病生存期的影响。
■发现总体生存率根据LNR（>0.06）和阳性节点数（>2）而显着变化。当LNR大于0.06时，GBC肿瘤的总生存率显着降低（63.37vs32.1，p0.005），但舌癌未见相同的趋势（55.61vs41.9，p0.98）。两组基于LNR的DFS没有差异。当存在>20个病理阳性淋巴结时,两组的总生存率显著降低,但两组的无病生存率没有显著变化。
■淋巴结比率（>0.06）和病理阳性淋巴结数（>2）在淋巴结阳性的口腔鳞状细胞癌中提供了更好的预后分层。发现口腔舌和GBC肿瘤对基于LNR的分层的总体存活率具有不同的影响。
对2014年1月至2017年12月在我们三级癌症研究所进行的498名以前未经治疗的OSCC患者进行了回顾性图表回顾。我们的分析包括133例经组织病理学证实有淋巴结转移的口腔舌和79例牙龈颊肿瘤。研究了LNR和阳性淋巴结数对总生存期和无病生存期的影响。
■发现总体生存率根据LNR（>0.06）和阳性节点数（>2）而显着变化。当LNR大于0.06时，GBC肿瘤的总生存率显着降低（63.37vs32.1，p0.005），但舌癌未见相同的趋势（55.61vs41.9，p0.98）。两组基于LNR的DFS没有差异。当存在>20个病理阳性淋巴结时,两组的总生存率显著降低,但两组的无病生存率没有显著变化。
■淋巴结比率（>0.06）和病理阳性淋巴结数（>2）在淋巴结阳性的口腔鳞状细胞癌中提供了更好的预后分层。发现口腔舌和GBC肿瘤对基于LNR的分层的总体存活率具有不同的影响。
