PDF(Pubmed)
Abstract：
UNASSIGNED: Cellular cannibalism (CC) is a prime metabolic event to determine the aggressive potential of oral squamous cell carcinoma (OSCC). However, the etiology and mechanism behind this degradation are still ambiguous. The aim of the study was to explore the etiopathogenetic mechanism behind CC, along with its association with degree of differentiation, angiogenic, phagocytic and antiapoptotic activity in OSCC.
UNASSIGNED: Seventy-three tissue sections of various histological grades of OSCC were retrieved from departmental archives and scanned for cannibalistic cells. Immunohistochemical analysis using CD31, CD68, and BCL2 was performed. The data obtained were analyzed using Chi-square, Spearman\'s correlation test and multiple regression analysis (p < 0.05).
UNASSIGNED: CCs were present significantly in various grades of OSCC (p < 0.00). Immunohistochemical analysis revealed a significant difference in CD68, BCL2 (p < 0.05 in both), and CD31 (p < 0.001) expression with CC. The internalized cells showed positivity for CD68 and negativity for BCL2. Regression analysis revealed that tumor grade, CD31 and BCL2 immunoreactivity were significant predictors of frequency of CC.
UNASSIGNED: The association of CC with degree of differentiation, CD31, CD68, and BCL2 expression could predict the biological behavior of OSCC and might serve as a promising histopathological parameter in future.
UNASSIGNED: Seventy-three tissue sections of various histological grades of OSCC were retrieved from departmental archives and scanned for cannibalistic cells. Immunohistochemical analysis using CD31, CD68, and BCL2 was performed. The data obtained were analyzed using Chi-square, Spearman\'s correlation test and multiple regression analysis (p < 0.05).
UNASSIGNED: CCs were present significantly in various grades of OSCC (p < 0.00). Immunohistochemical analysis revealed a significant difference in CD68, BCL2 (p < 0.05 in both), and CD31 (p < 0.001) expression with CC. The internalized cells showed positivity for CD68 and negativity for BCL2. Regression analysis revealed that tumor grade, CD31 and BCL2 immunoreactivity were significant predictors of frequency of CC.
UNASSIGNED: The association of CC with degree of differentiation, CD31, CD68, and BCL2 expression could predict the biological behavior of OSCC and might serve as a promising histopathological parameter in future.
摘要：
■细胞相食（CC）是确定口腔鳞状细胞癌（OSCC）侵袭潜力的主要代谢事件。然而,这种退化背后的病因和机制仍然模棱两可。这项研究的目的是探索CC背后的病因机制，以及它与分化程度的联系，血管生成,OSCC中的吞噬和抗凋亡活性。
■从部门档案中检索了73个不同组织学等级的OSCC组织切片，并扫描了食人细胞。使用CD31、CD68和BCL2进行免疫组织化学分析。使用卡方分析获得的数据，Spearman相关检验和多元回归分析(p<0.05)。
■CCs在不同等级的OSCC中显著存在(p<0.00)。免疫组织化学分析显示CD68、BCL2有显著差异(两者p<0.05),和CD31(p<0.001)表达与CC。内化细胞显示CD68阳性和BCL2阴性。回归分析显示肿瘤分级,CD31和BCL2免疫反应性是CC频率的重要预测因子。
■CC与分化程度的关联，CD31，CD68和BCL2的表达可以预测OSCC的生物学行为，并可能成为将来有希望的组织病理学参数。
■从部门档案中检索了73个不同组织学等级的OSCC组织切片，并扫描了食人细胞。使用CD31、CD68和BCL2进行免疫组织化学分析。使用卡方分析获得的数据，Spearman相关检验和多元回归分析(p<0.05)。
■CCs在不同等级的OSCC中显著存在(p<0.00)。免疫组织化学分析显示CD68、BCL2有显著差异(两者p<0.05),和CD31(p<0.001)表达与CC。内化细胞显示CD68阳性和BCL2阴性。回归分析显示肿瘤分级,CD31和BCL2免疫反应性是CC频率的重要预测因子。
■CC与分化程度的关联，CD31，CD68和BCL2的表达可以预测OSCC的生物学行为，并可能成为将来有希望的组织病理学参数。
