PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to analyse the independent prognostic significance of perineural invasion (PNI) on local recurrence (LR) in patients with oral squamous cell carcinoma (OSCC) managed primarily with surgery.
UNASSIGNED: Clinical and histopathological data of 195 patients with OSCC were analysed retrospectively to identify risk factors associated with PNI and to evaluate its significant correlation with local recurrence, overall survival (OS) and recurrence free survival (RFS).
UNASSIGNED: Patients were followed for a mean period of 39.5 ± 1.376 months and median 35 months. PNI was found in 57 patients (29.2%). PNI correlated with tongue subsite (p = 0.001), nodal metastasis (p < 0.000), depth of invasion (DOI) (p = 0.002), stage (p = 0.013) and adjuvant therapy (p < 0.001). Mean time to recurrence with PNI was significantly shorter (p = 0.002).Multivariate analysis did not establish significant relationship between PNI and LR. Kaplan-Meier curve did not show statistical significance with OS (p = 0.085) or RFS (p = 0.110).
UNASSIGNED: PNI remains an aggressive factor for nodal metastasis mandating neck management for regional control. Though PNI showed no statistical significance with LR, time to recurrence in PNI positive patients were significantly shorter. Hence, close follow-up regimen becomes necessary.
UNASSIGNED: Clinical and histopathological data of 195 patients with OSCC were analysed retrospectively to identify risk factors associated with PNI and to evaluate its significant correlation with local recurrence, overall survival (OS) and recurrence free survival (RFS).
UNASSIGNED: Patients were followed for a mean period of 39.5 ± 1.376 months and median 35 months. PNI was found in 57 patients (29.2%). PNI correlated with tongue subsite (p = 0.001), nodal metastasis (p < 0.000), depth of invasion (DOI) (p = 0.002), stage (p = 0.013) and adjuvant therapy (p < 0.001). Mean time to recurrence with PNI was significantly shorter (p = 0.002).Multivariate analysis did not establish significant relationship between PNI and LR. Kaplan-Meier curve did not show statistical significance with OS (p = 0.085) or RFS (p = 0.110).
UNASSIGNED: PNI remains an aggressive factor for nodal metastasis mandating neck management for regional control. Though PNI showed no statistical significance with LR, time to recurrence in PNI positive patients were significantly shorter. Hence, close follow-up regimen becomes necessary.
摘要：
■本研究的目的是分析主要通过手术治疗的口腔鳞状细胞癌（OSCC）患者的神经周浸润（PNI）对局部复发（LR）的独立预后意义。
■对195例OSCC患者的临床和组织病理学资料进行回顾性分析，以确定与PNI相关的危险因素，并评估其与局部复发的显著相关性，总生存期（OS）和无复发生存期（RFS）。
■患者的平均随访时间为39.5±1.376个月，中位数为35个月。在57例患者中发现了PNI（29.2％）。PNI与舌亚位点相关(p=0.001)，淋巴结转移（p<0.000），侵入深度（DOI）（p=0.002），分期(p=0.013)和辅助治疗(p<0.001)。PNI的平均复发时间显著缩短(p=0.002)。多因素分析未建立PNI和LR之间的显著关系。Kaplan-Meier曲线对OS(p=0.085)或RFS(p=0.110)无统计学意义。
■PNI仍然是淋巴结转移的侵袭性因素，要求对颈部进行区域控制。尽管PNI与LR没有统计学意义，PNI阳性患者的复发时间显著缩短.因此，密切随访方案变得必要。
■对195例OSCC患者的临床和组织病理学资料进行回顾性分析，以确定与PNI相关的危险因素，并评估其与局部复发的显著相关性，总生存期（OS）和无复发生存期（RFS）。
■患者的平均随访时间为39.5±1.376个月，中位数为35个月。在57例患者中发现了PNI（29.2％）。PNI与舌亚位点相关(p=0.001)，淋巴结转移（p<0.000），侵入深度（DOI）（p=0.002），分期(p=0.013)和辅助治疗(p<0.001)。PNI的平均复发时间显著缩短(p=0.002)。多因素分析未建立PNI和LR之间的显著关系。Kaplan-Meier曲线对OS(p=0.085)或RFS(p=0.110)无统计学意义。
■PNI仍然是淋巴结转移的侵袭性因素，要求对颈部进行区域控制。尽管PNI与LR没有统计学意义，PNI阳性患者的复发时间显著缩短.因此，密切随访方案变得必要。
