PDF(Pubmed)
Abstract：
UNASSIGNED: The present review article aims to compile the best available evidence-based data on oral metronomic chemotherapy (OMCT) including its mechanism of action, its utility, and future directions.
UNASSIGNED: A systematic search was carried out in PubMed database for available English literature from last 10 years between 2011 and 2021. Keyword combinations used were \'Oral Metronomic chemotherapy for oral cancer, mechanism of action of OMCT, Oral metronomic chemotherapy in India, OMCT in recurrent and palliative treatment of oral cancers.\'
UNASSIGNED: Multitudes of studies have been published recently stating the role of OMCT in head and neck squamous cell carcinoma (HNSCC), but the studies with the category of level of evidence required to advocate OMCT as a recognized therapy are still scarce. On careful stratification of these studies, we found that OMCT has a lot to offer in palliative settings, recurrent, and metastatic HNSCC. There is some limited evidence of its role in adjuvant therapy as maintenance and in neoadjuvant setting.
UNASSIGNED: With current evidence, there is a definite role of OMCT in treatment of oral SCC. OMCT can be an alternative in patients who are not tolerable or affordable for standard palliative chemotherapy and also an option for patient who are waiting for surgery. However, results of ongoing and future studies on exact mechanism, indications, and implications of this drug regimen would help in integration OMCT in current standard of therapy.
UNASSIGNED:
UNASSIGNED: A systematic search was carried out in PubMed database for available English literature from last 10 years between 2011 and 2021. Keyword combinations used were \'Oral Metronomic chemotherapy for oral cancer, mechanism of action of OMCT, Oral metronomic chemotherapy in India, OMCT in recurrent and palliative treatment of oral cancers.\'
UNASSIGNED: Multitudes of studies have been published recently stating the role of OMCT in head and neck squamous cell carcinoma (HNSCC), but the studies with the category of level of evidence required to advocate OMCT as a recognized therapy are still scarce. On careful stratification of these studies, we found that OMCT has a lot to offer in palliative settings, recurrent, and metastatic HNSCC. There is some limited evidence of its role in adjuvant therapy as maintenance and in neoadjuvant setting.
UNASSIGNED: With current evidence, there is a definite role of OMCT in treatment of oral SCC. OMCT can be an alternative in patients who are not tolerable or affordable for standard palliative chemotherapy and also an option for patient who are waiting for surgery. However, results of ongoing and future studies on exact mechanism, indications, and implications of this drug regimen would help in integration OMCT in current standard of therapy.
UNASSIGNED:
摘要：
■本综述文章旨在汇编有关口服节拍化疗（OMCT）的最佳证据数据，包括其作用机制，其效用,和未来的方向。
■在PubMed数据库中进行了系统搜索，以获取2011年至2021年过去10年的可用英语文献。使用的关键词组合是口腔癌的口服节理化疗，OMCT的作用机制，印度的口服节拍化疗，OMCT在口腔癌复发和姑息治疗中的应用。\'
■最近发表了大量研究，说明了OMCT在头颈部鳞状细胞癌（HNSCC）中的作用，但主张将OMCT作为公认治疗所需的证据水平类别的研究仍然很少.仔细分层这些研究，我们发现OMCT在姑息治疗中可以提供很多服务，经常性,和转移性HNSCC。有一些有限的证据表明其在维持辅助治疗和新辅助治疗中的作用。
■根据目前的证据，OMCT在口腔SCC的治疗中有明确的作用。OMCT可以作为标准姑息性化疗不可耐受或负担得起的患者的替代方案，也是等待手术的患者的一种选择。然而,关于确切机制的正在进行和未来研究的结果，适应症,并且该药物方案的含义将有助于将OMCT整合到当前的治疗标准中。
■
■在PubMed数据库中进行了系统搜索，以获取2011年至2021年过去10年的可用英语文献。使用的关键词组合是口腔癌的口服节理化疗，OMCT的作用机制，印度的口服节拍化疗，OMCT在口腔癌复发和姑息治疗中的应用。\'
■最近发表了大量研究，说明了OMCT在头颈部鳞状细胞癌（HNSCC）中的作用，但主张将OMCT作为公认治疗所需的证据水平类别的研究仍然很少.仔细分层这些研究，我们发现OMCT在姑息治疗中可以提供很多服务，经常性,和转移性HNSCC。有一些有限的证据表明其在维持辅助治疗和新辅助治疗中的作用。
■根据目前的证据，OMCT在口腔SCC的治疗中有明确的作用。OMCT可以作为标准姑息性化疗不可耐受或负担得起的患者的替代方案，也是等待手术的患者的一种选择。然而,关于确切机制的正在进行和未来研究的结果，适应症,并且该药物方案的含义将有助于将OMCT整合到当前的治疗标准中。
■
