PDF(Pubmed)
Abstract：
UNASSIGNED: Improved treatments for children with congenital heart disease (CHD) have led to a growing interest in long-term functional outcomes such as health-related quality of life (HRQOL). Studies on HRQOL in children with CHD have yielded contradictory results. In this study, we aimed to perform a systematic review and meta-analysis to analyze the effect of surgery on HRQOL outcomes in children with CHD in low-income and middle-income countries.
UNASSIGNED: A comprehensive search for articles was performed using the Medline (PubMed), Scopus, and Embase databases from their inception to September 5, 2023. Studies reporting QOL outcomes in children <18 years and published in English were included.
UNASSIGNED: Of the 1239 records screened, 10 studies, including 1721 participants, were included in the study. The overall QOL was significantly better in the control group than in the children who underwent surgery for CHD (P=0.04, standard mean difference of -0.62, 95% CI: -1.2 to -0.04), and the overall QOL was significantly better in the children with CHD after surgery than before surgery (P=0.05, standard mean difference of -0.56, 95% CI: -1.11 to -0.01).
UNASSIGNED: The QOL of children from low-income and middle-income countries who undergo surgery for CHD is significantly poorer than that of controls in all dimensions except the emotional domain. Meanwhile, surgery has the greatest impact on improving the physical domain in children with CHD after surgery. Strategies to improve HRQOL in this subgroup of patients should be further investigated.
UNASSIGNED: A comprehensive search for articles was performed using the Medline (PubMed), Scopus, and Embase databases from their inception to September 5, 2023. Studies reporting QOL outcomes in children <18 years and published in English were included.
UNASSIGNED: Of the 1239 records screened, 10 studies, including 1721 participants, were included in the study. The overall QOL was significantly better in the control group than in the children who underwent surgery for CHD (P=0.04, standard mean difference of -0.62, 95% CI: -1.2 to -0.04), and the overall QOL was significantly better in the children with CHD after surgery than before surgery (P=0.05, standard mean difference of -0.56, 95% CI: -1.11 to -0.01).
UNASSIGNED: The QOL of children from low-income and middle-income countries who undergo surgery for CHD is significantly poorer than that of controls in all dimensions except the emotional domain. Meanwhile, surgery has the greatest impact on improving the physical domain in children with CHD after surgery. Strategies to improve HRQOL in this subgroup of patients should be further investigated.
摘要：
■先天性心脏病（CHD）患儿的治疗方法的改进导致对长期功能结果（如与健康相关的生活质量（HRQOL））的兴趣与日俱增。对CHD儿童HRQOL的研究得出了矛盾的结果。在这项研究中,我们旨在进行系统评价和荟萃分析,分析低收入和中等收入国家的CHD患儿手术对HRQOL结局的影响.
■使用Medline（PubMed）对文章进行了全面搜索，Scopus,和Embase数据库从成立到2023年9月5日。包括报告18岁以下儿童生活质量结果并以英文发表的研究。
■在筛选的1239条记录中，10研究,包括1721名参与者，包括在研究中。对照组的总体生活质量明显优于接受冠心病手术的儿童（P=0.04，标准平均差为-0.62，95％CI：-1.2至-0.04），冠心病患儿手术后的总体生活质量明显优于手术前（P=0.05，标准均差-0.56，95％CI：-1.11至-0.01）。
■接受冠心病手术的低收入和中等收入国家儿童的生活质量在除情感领域外的所有方面都明显低于对照组。同时,手术对改善CHD患儿术后体质的影响最大。应进一步研究改善此亚组患者HRQOL的策略。
■使用Medline（PubMed）对文章进行了全面搜索，Scopus,和Embase数据库从成立到2023年9月5日。包括报告18岁以下儿童生活质量结果并以英文发表的研究。
■在筛选的1239条记录中，10研究,包括1721名参与者，包括在研究中。对照组的总体生活质量明显优于接受冠心病手术的儿童（P=0.04，标准平均差为-0.62，95％CI：-1.2至-0.04），冠心病患儿手术后的总体生活质量明显优于手术前（P=0.05，标准均差-0.56，95％CI：-1.11至-0.01）。
■接受冠心病手术的低收入和中等收入国家儿童的生活质量在除情感领域外的所有方面都明显低于对照组。同时,手术对改善CHD患儿术后体质的影响最大。应进一步研究改善此亚组患者HRQOL的策略。
