关键词: Brugada syndrome fever malaria

来  源:   DOI:10.1097/MS9.0000000000002286   PDF(Pubmed)

Abstract:
UNASSIGNED: Brugada syndrome (BrS) is a rare genetic disorder with specific electrocardiographic (ECG) patterns carrying an increased risk of sudden cardiac death.
UNASSIGNED: The authors present a 36-year-old gentleman who had a travel history to the Central African Republic and came to the hospital with a fever and chest pain. The lab investigation revealed Falciparum Malaria infection and the ECG pattern revealed the type 1 Brugada pattern, which was normalized with anti-malarial medication and symptomatic treatment of fever.
UNASSIGNED: BrS is a disorder with high prevalence in males and people of the Asian continent. Patients can present with symptoms like syncope, seizure, and nocturnal agonal respiration or may be asymptomatic. The ECG pattern of BrS could be seen in the febrile phase and normalized when non-febrile, like in our patient. Prompt treatment of fever and follow-up with cardiologists would be an effective treatment of asymptomatic patients, whereas ICD is a management of choice for symptomatic patients.
UNASSIGNED: For a patient with chest pain, fever, and an ECG pattern of ST elevation, a clinician should think BrS one of the differential diagnoses.
摘要:
Brugada综合征(BrS)是一种罕见的遗传性疾病,具有特定的心电图(ECG)模式,导致心源性猝死的风险增加。
作者介绍了一位36岁的绅士,他有前往中非共和国的旅行史,并因发烧和胸痛来到医院。实验室调查显示恶性疟原虫疟疾感染,心电图显示1型Brugada模式,通过抗疟疾药物和发烧的对症治疗使其正常化。
BrS是一种在亚洲大陆男性和人群中患病率很高的疾病。患者会出现晕厥等症状,癫痫发作,和夜间阵性呼吸或可能无症状。在发热期可以看到BrS的ECG模式,在非发热时可以归一化,就像我们的病人一样。及时治疗发烧和心脏病专家的随访将是无症状患者的有效治疗方法,而ICD是有症状患者的首选治疗方法.
对于胸痛患者,发烧,和心电图ST段抬高,临床医生应将BrS视为鉴别诊断之一.
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