Abstract：
Calcinosis cutis is defined as the deposition of calcium salts in the skin. The dystrophic form is the most common and usually occurs in chronic inflammatory processes associated with collagenoses. Therapeutic options include surgical excision as well as a few pharmacological treatments. Overall, the evidence for the known therapeutic interventions is very limited and there is a lack of valid recommendations. Intravenous sodium thiosulfate has been used successfully in the treatment of calciphylaxis. In our case series, five patients with dystrophic calcinosis cutis received intravenous sodium thiosulfate for at least six cycles on five consecutive days per month, with single doses of 12.5 g and 25.0 g, respectively. A reduction in the calcified lesions could not be proven with certainty, but stable disease conditions were achieved. Intravenous sodium thiosulfate may counteract the progression of calcinosis cutis. The successful use of epicutaneously applied sodium thiosulfate, as described in the literature, suggests that a higher cutaneous bioavailability can be achieved to exert a lytic effect on calcinosis cutis. This is further supported by the reported efficacy of high-dose sodium thiosulfate in the treatment of calciphylaxis.
摘要：
角质病定义为钙盐在皮肤中的沉积。营养不良形式是最常见的，通常发生在与胶原病相关的慢性炎症过程中。治疗选择包括手术切除以及一些药物治疗。总的来说,已知治疗性干预措施的证据非常有限,缺乏有效的建议.静脉注射硫代硫酸钠已成功用于治疗钙化。在我们的案例系列中，5例营养不良性钙质沉着症患者每月连续五天接受至少6个周期的硫代硫酸钠静脉注射，单次剂量为12.5g和25.0g，分别。钙化病变的减少无法确定，但病情稳定。静脉注射硫代硫酸钠可以抵消皮肤钙质沉着的进展。成功使用皮下应用硫代硫酸钠，正如文献中所描述的，表明可以实现更高的皮肤生物利用度，以对钙质角质层产生溶解作用。据报道，高剂量硫代硫酸钠在治疗钙化中的功效进一步支持了这一点。
