Abstract：
UNASSIGNED: One complication of restorative proctocolectomy with ileo-anal pouch anastomosis is fistula formation in the pouch. Fistulas can be associated with significant morbidity and pouch failure. We conducted a systematic review with meta- analysis to try and understand the prevalence of pouch fistulas in patients with ulcerative colitis following restorative proctocolectomy.
UNASSIGNED: The Embase, Embase Classic, and PubMed databases were searched between January 1979 and April 2022. Studies were included if there were cross-sectional, case-controlled, population-based or cohort studies reporting on prevalence of pouch fistulas in ulcerative colitis. Studies had to report the number of patients with pouch fistulas using either clinical, endoscopic, or radiological diagnosis in an adult population.
UNASSIGNED: Thirty-three studies screened met the inclusion criteria. The pooled prevalence of developing at least 1 fistula was 0.05 (95% confidence interval [CI], 0.04-0.07). The pooled prevalence of pouch failure in patients with pouch fistula was found to be 0.24 (95% CI, 0.19-0.30). The pooled prevalence of developing a pouch fistula at 3 years, 5 years and more than 5 years was 0.04 (95% CI, 0.02-0.07), 0.05 (95% CI, 0.02-0.07), and 0.05 (95% CI, 0.02-0.10), respectively.
UNASSIGNED: This is the first systematic review and meta-analysis to report the prevalence of pouch fistula. It also provides a pooled prevalence of pouch failure in these patients. These results can help to shape future guidelines, power future studies, and help counsel patients.
UNASSIGNED: The Embase, Embase Classic, and PubMed databases were searched between January 1979 and April 2022. Studies were included if there were cross-sectional, case-controlled, population-based or cohort studies reporting on prevalence of pouch fistulas in ulcerative colitis. Studies had to report the number of patients with pouch fistulas using either clinical, endoscopic, or radiological diagnosis in an adult population.
UNASSIGNED: Thirty-three studies screened met the inclusion criteria. The pooled prevalence of developing at least 1 fistula was 0.05 (95% confidence interval [CI], 0.04-0.07). The pooled prevalence of pouch failure in patients with pouch fistula was found to be 0.24 (95% CI, 0.19-0.30). The pooled prevalence of developing a pouch fistula at 3 years, 5 years and more than 5 years was 0.04 (95% CI, 0.02-0.07), 0.05 (95% CI, 0.02-0.07), and 0.05 (95% CI, 0.02-0.10), respectively.
UNASSIGNED: This is the first systematic review and meta-analysis to report the prevalence of pouch fistula. It also provides a pooled prevalence of pouch failure in these patients. These results can help to shape future guidelines, power future studies, and help counsel patients.
摘要：
■回肠肛门袋吻合的恢复性直肠结肠切除术的一个并发症是袋内瘘的形成。瘘可与显著的发病率和囊衰竭相关。我们进行了系统评价和元分析，试图了解溃疡性结肠炎患者在恢复性直肠结肠切除术后的袋瘘患病率。
■Embase，EmbaseClassic,和PubMed数据库在1979年1月至2022年4月之间进行了搜索。如果有横断面研究，病例控制,基于人群或队列的研究报告了溃疡性结肠炎中袋瘘的患病率.研究必须报告使用两种临床方法的囊袋瘘患者数量，内窥镜,或成人的放射学诊断。
■筛选的33项研究符合纳入标准。发生至少1个瘘管的合并患病率为0.05(95%置信区间[CI]，0.04-0.07)。发现囊袋瘘患者囊袋衰竭的合并患病率为0.24（95％CI，0.19-0.30）。3年时发生囊袋瘘的合并患病率，5年和5年以上为0.04(95%CI，0.02-0.07)，0.05（95%CI，0.02-0.07），和0.05（95%CI，0.02-0.10），分别。
■这是首次报道囊袋瘘患病率的系统评价和荟萃分析。它还提供了这些患者的囊袋衰竭的合并患病率。这些结果可以帮助形成未来的指导方针，为未来的研究提供动力，并帮助患者提供咨询。
■Embase，EmbaseClassic,和PubMed数据库在1979年1月至2022年4月之间进行了搜索。如果有横断面研究，病例控制,基于人群或队列的研究报告了溃疡性结肠炎中袋瘘的患病率.研究必须报告使用两种临床方法的囊袋瘘患者数量，内窥镜,或成人的放射学诊断。
■筛选的33项研究符合纳入标准。发生至少1个瘘管的合并患病率为0.05(95%置信区间[CI]，0.04-0.07)。发现囊袋瘘患者囊袋衰竭的合并患病率为0.24（95％CI，0.19-0.30）。3年时发生囊袋瘘的合并患病率，5年和5年以上为0.04(95%CI，0.02-0.07)，0.05（95%CI，0.02-0.07），和0.05（95%CI，0.02-0.10），分别。
■这是首次报道囊袋瘘患病率的系统评价和荟萃分析。它还提供了这些患者的囊袋衰竭的合并患病率。这些结果可以帮助形成未来的指导方针，为未来的研究提供动力，并帮助患者提供咨询。
