改善细胞周期蛋白依赖性激酶 4 / 6 抑制剂的口服药物动力学的策略 : 通过天然生物增强剂增强渗透性和 CYP450 抑制。
关键词: CDK4/6 inhibitors bio-enhancer bioavailability dietary flavonoids naringin pharmacokinetics
Mesh : Animals Humans Rats Administration, Oral Aminopyridines / pharmacokinetics pharmacology administration & dosage ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism antagonists & inhibitors Bioenhancers / pharmacology Biological Availability Caco-2 Cells Cyclin-Dependent Kinase 4 / antagonists & inhibitors metabolism Cyclin-Dependent Kinase 6 / antagonists & inhibitors Cytochrome P-450 CYP3A / metabolism Cytochrome P-450 Enzyme Inhibitors / pharmacology administration & dosage Flavanones / administration & dosage pharmacology Molecular Docking Simulation Permeability Piperazines / pharmacokinetics pharmacology administration & dosage Protein Kinase Inhibitors / administration & dosage pharmacokinetics Purines / pharmacokinetics administration & dosage pharmacology Pyridines / pharmacokinetics pharmacology administration & dosage Rats, Sprague-Dawley
来 源: DOI:10.1208/s12249-024-02899-3