Abstract：
HIV infection triggers an inflammatory response that manifests as acute retroviral syndrome (ARS) in most individuals infected by HIV. While this syndrome is usually self-limited, primary HIV infection sometimes triggers a fulminant inflammatory process consistent with cytokine storm syndrome (CSS). Many of the key findings of CSS including fever, splenomegaly, and cytopenias are routinely observed in ARS, suggesting CSS may be under recognized in the setting of acute HIV infection. Unlike other CSS scenarios, ARS-associated CSS generally responds well to HIV-targeted therapies. Advanced HIV infection is also associated with CSS, although typically this involves additional infectious insults. Occasionally, HIV therapy results in rapid recovery of the immune response that evolves into CSS.
摘要：
HIV感染引发炎症反应，在大多数HIV感染的个体中表现为急性逆转录病毒综合征（ARS）。虽然这种综合征通常是自我限制的，原发性HIV感染有时会引发与细胞因子风暴综合征（CSS）一致的暴发性炎症过程。CSS的许多关键发现，包括发烧，脾肿大,在ARS中经常观察到血细胞减少，提示CSS在急性HIV感染的背景下可能未得到认可。与其他CSS场景不同，ARS相关的CSS通常对HIV靶向治疗反应良好。晚期HIV感染也与CSS有关，尽管这通常涉及额外的感染性侮辱。偶尔,HIV治疗导致进化为CSS的免疫应答的快速恢复。
