Abstract:
Cytokine storm syndromes (CSSs) are caused by a dysregulated host immune response to an inciting systemic inflammatory trigger. This maladaptive and harmful immune response culminates in collateral damage to host tissues resulting in life-threatening multisystem organ failure. Knowledge of the various immune cells that contribute to CSS pathogenesis has improved dramatically in the past decade. Monocytes, dendritic cells, and macrophages, collective known as monocytic phagocytes, are well-positioned within the immune system hierarchy to make key contributions to the initiation, propagation, and amplification of the hyperinflammatory response in CSS. The plasticity of monocytic phagocytes also makes them prime candidates for mediating immunoregulatory and tissue-healing functions in patients who recover from cytokine storm-mediated immunopathology. Therefore, approaches to manipulate the myriad functions of monocytic phagocytes may improve the clinical outcome of CSS.
摘要:
细胞因子风暴综合征(CSS)是由宿主对诱发全身性炎症触发的免疫反应失调引起的。这种适应不良和有害的免疫反应最终导致对宿主组织的附带损害,导致危及生命的多系统器官衰竭。在过去的十年中,对有助于CSS发病机理的各种免疫细胞的了解得到了显着改善。单核细胞,树突状细胞,和巨噬细胞,被称为单核细胞吞噬细胞的集合,在免疫系统层次结构中处于有利位置,对启动做出关键贡献,传播,和CSS中炎症反应的放大。单核细胞吞噬细胞的可塑性也使其成为从细胞因子风暴介导的免疫病理学恢复的患者中介导免疫调节和组织愈合功能的主要候选者。因此,操纵单核细胞吞噬细胞多种功能的方法可能会改善CSS的临床结果。