Abstract：
OBJECTIVE: We report the second case of bilateral sudden sensorineural hearing loss with intracochlear fibrosis due to chronic myeloid leukemia.
METHODS: A 44-year-old man presented to the emergency department with rapidly progressive bilateral hearing loss, tinnitus and vertigo, associated with dyspnea. Chronic myeloid leukemia complicated by pulmonary and cochleovestibular leukostasis was diagnosed, and cytoreductive treatment was started. Despite this treatment, bilateral total hearing loss and complete vestibular deficit persisted. MRI showed bilateral labyrinthitis, and emergency cochlear implantation was indicated. During surgery, inflammatory intracochlear tissue made electrode array insertion possible only against resistance. One year after implantation, there was significant improvement in speech recognition and communication scores.
CONCLUSIONS: In case of sudden sensorineural hearing loss induced by chronic myeloid leukemia, treatment should be as fast as possible, with prompt cochlear implantation in case of definitive profound hearing loss, because of the risk of cochlear fibrosis and ossification.
METHODS: A 44-year-old man presented to the emergency department with rapidly progressive bilateral hearing loss, tinnitus and vertigo, associated with dyspnea. Chronic myeloid leukemia complicated by pulmonary and cochleovestibular leukostasis was diagnosed, and cytoreductive treatment was started. Despite this treatment, bilateral total hearing loss and complete vestibular deficit persisted. MRI showed bilateral labyrinthitis, and emergency cochlear implantation was indicated. During surgery, inflammatory intracochlear tissue made electrode array insertion possible only against resistance. One year after implantation, there was significant improvement in speech recognition and communication scores.
CONCLUSIONS: In case of sudden sensorineural hearing loss induced by chronic myeloid leukemia, treatment should be as fast as possible, with prompt cochlear implantation in case of definitive profound hearing loss, because of the risk of cochlear fibrosis and ossification.
摘要：
目的：我们报告了第二例因慢性粒细胞白血病引起的双侧突发性感音神经性听力损失伴耳蜗内纤维化。
方法：一名44岁男子因迅速进展的双侧听力损失出现在急诊科，耳鸣和眩晕,与呼吸困难有关。诊断为慢性粒细胞白血病并发肺和耳蜗前庭白细胞淤滞，并开始细胞还原治疗。尽管有这样的治疗,双侧总听力损失和完全性前庭缺损持续存在.MRI显示双侧迷路炎,急诊人工耳蜗植入术。手术期间,炎性耳蜗内组织使电极阵列插入只能抵抗阻力。植入后一年，语音识别和沟通得分有显著改善.
结论：在慢性粒细胞白血病引起的突发性感觉神经性听力损失的情况下，治疗应尽可能快，在明确的严重听力损失的情况下迅速植入耳蜗，因为耳蜗纤维化和骨化的风险。
方法：一名44岁男子因迅速进展的双侧听力损失出现在急诊科，耳鸣和眩晕,与呼吸困难有关。诊断为慢性粒细胞白血病并发肺和耳蜗前庭白细胞淤滞，并开始细胞还原治疗。尽管有这样的治疗,双侧总听力损失和完全性前庭缺损持续存在.MRI显示双侧迷路炎,急诊人工耳蜗植入术。手术期间,炎性耳蜗内组织使电极阵列插入只能抵抗阻力。植入后一年，语音识别和沟通得分有显著改善.
结论：在慢性粒细胞白血病引起的突发性感觉神经性听力损失的情况下，治疗应尽可能快，在明确的严重听力损失的情况下迅速植入耳蜗，因为耳蜗纤维化和骨化的风险。
