Abstract：
Via retrospective isolation of clones using Rewind, Jain et al. identified primed states of cells that reprogram to induced pluripotent stem cells. Examining clones, they find that cells retain memory of over several rounds of cell division. Moreover, they show that extrinsic factors change the number of primed cells, suggesting that there exist diverse paths of reprogramming and states of priming.
摘要：
通过使用Rewind对克隆进行回顾性分离，Jain等人。鉴定了重编程为诱导多能干细胞的细胞的启动状态。检查克隆，他们发现细胞保留了几轮细胞分裂的记忆。此外，他们表明外在因素改变了引发细胞的数量，这表明存在不同的重编程路径和启动状态。
