Abstract：
OBJECTIVE: Impact of osteoarthritis (OA) on the initial treatment response of rheumatoid arthritis (RA) by treat to target (T2T) practice was compared between the patients with an onset age ≥65 years old (late-onset RA [LORA]) and those with an onset age <65 years old (young-onset RA [YORA]).
METHODS: A retrospective study was conducted on the patients with RA, who were referred to our clinic without treatment between January 2021 and July 2022. Patients with grade ≥3 OA according to the Kellgren-Lawrence (K-L) classification either in the knee or hand were classified in the OA(+) group and others were in the OA(-) group. The clinical data were compared at the diagnosis and one year after the initial treatment between the groups for 74 LORA and 59 YORA patients, respectively.
RESULTS: One year after starting treatment in the LORA patients, the OA(+) group had poorer disease activity control and greater disability in the several activities of daily living (ADL) than the OA(-) group. In the YORA patients, there were no differences in ADL disability between the groups.
CONCLUSIONS: In the initial treatment of the LORA patients, the prevalence of OA was high, and impact of OA on LORA was larger than on YORA.
METHODS: A retrospective study was conducted on the patients with RA, who were referred to our clinic without treatment between January 2021 and July 2022. Patients with grade ≥3 OA according to the Kellgren-Lawrence (K-L) classification either in the knee or hand were classified in the OA(+) group and others were in the OA(-) group. The clinical data were compared at the diagnosis and one year after the initial treatment between the groups for 74 LORA and 59 YORA patients, respectively.
RESULTS: One year after starting treatment in the LORA patients, the OA(+) group had poorer disease activity control and greater disability in the several activities of daily living (ADL) than the OA(-) group. In the YORA patients, there were no differences in ADL disability between the groups.
CONCLUSIONS: In the initial treatment of the LORA patients, the prevalence of OA was high, and impact of OA on LORA was larger than on YORA.
摘要：
目的：在发病年龄≥65岁的患者（晚发性RA[LORA]）和发病年龄<65岁的患者（青年性RA[YORA]）之间，比较骨关节炎（OA）对类风湿性关节炎（RA）初始治疗反应的影响。
方法：对RA患者进行回顾性研究，他们在2021年1月至2022年7月期间被转诊到我们的诊所，没有接受治疗。根据Kellgren-Lawrence（K-L）分类，膝关节或手部的OA等级≥3的患者被分类为OA（）组，其他患者被分类为OA（-）组。对74例LORA和59例YORA患者在诊断时和初始治疗后一年的临床数据进行了比较，分别。
结果：LORA患者开始治疗一年后，与OA(-)组相比,OA(+)组的疾病活动控制较差,而日常生活活动(ADL)的残疾程度更大.在YORA患者中,两组间ADL残疾无差异.
结论：在LORA患者的初始治疗中，OA的患病率很高，OA对LORA的影响大于对YORA的影响。
方法：对RA患者进行回顾性研究，他们在2021年1月至2022年7月期间被转诊到我们的诊所，没有接受治疗。根据Kellgren-Lawrence（K-L）分类，膝关节或手部的OA等级≥3的患者被分类为OA（）组，其他患者被分类为OA（-）组。对74例LORA和59例YORA患者在诊断时和初始治疗后一年的临床数据进行了比较，分别。
结果：LORA患者开始治疗一年后，与OA(-)组相比,OA(+)组的疾病活动控制较差,而日常生活活动(ADL)的残疾程度更大.在YORA患者中,两组间ADL残疾无差异.
结论：在LORA患者的初始治疗中，OA的患病率很高，OA对LORA的影响大于对YORA的影响。
