Abstract：
Selective autophagic degradation of cellular components has been shown to be mediated by the interaction of LIR motif-containing proteins with ATG8-family proteins. Here, we present a detailed methodology for the in silico evaluation of potential binding between LIR motif-containing proteins and ATG8-family proteins. We visualize AlphaFold-predicted protein complexes using PyMOL to assess potential interactions, providing an effective computational tool for this purpose.
摘要：
已显示细胞组分的选择性自噬降解是由含LIR基序的蛋白与ATG8家族蛋白的相互作用介导的。这里,我们提供了一种详细的方法，用于计算机评估含LIR基序的蛋白质与ATG8家族蛋白质之间的潜在结合。我们使用PyMOL可视化AlphaFold预测的蛋白质复合物，以评估潜在的相互作用，为此提供了一种有效的计算工具。
