PDF(Pubmed)
Abstract：
UNASSIGNED: Esophagogastroduodenoscopy (EGD) is a fundamental procedure for early detection of upper gastrointestinal (UGI) cancer. However, limited research has been conducted on the impact of sedation during EGD on the identification of precancerous lesions and early cancer (EC). This retrospective study aims to evaluate whether sedation during EGD can improve the detection rates of precancerous lesions and EC.
UNASSIGNED: In this propensity score-matched retrospective study, we examined medical records from outpatients who underwent diagnostic EGD at a large tertiary center between January 2023 and December 2023. Data on endoscopic findings and histology biopsies were obtained from an endoscopy quality-control system. The primary objective was to compare the rates of detecting precancerous lesions and EC in patients who received sedation during EGD vs. those who did not receive sedation. Additionally, we aimed to identify factors influencing these detection rates using binary logistic regression analysis.
UNASSIGNED: Following propensity score matching, a total of 17,862 patients who underwent diagnostic EGD with or without propofol sedation were identified. The group that received sedation exhibited a higher detection rate of precancerous lesions and EC in comparison to the non-sedated group (1.04 vs. 0.75%; p = 0.039). Additionally, within the sedated group, there was an increased likelihood of identifying precancerous lesions and EC specifically at the gastric antrum (0.60 vs. 0.32%, p = 0.006). Binary logistic regression analysis demonstrated that independent risk factors influencing the detection rates included age, gender, observation time, and number of biopsies conducted during the procedure.
UNASSIGNED: Anesthesia assistance during EGD screening proved advantageous in detecting EC as well as precancerous lesions. It is crucial for endoscopists to consider these factors when performing EGD screening procedures.
UNASSIGNED: In this propensity score-matched retrospective study, we examined medical records from outpatients who underwent diagnostic EGD at a large tertiary center between January 2023 and December 2023. Data on endoscopic findings and histology biopsies were obtained from an endoscopy quality-control system. The primary objective was to compare the rates of detecting precancerous lesions and EC in patients who received sedation during EGD vs. those who did not receive sedation. Additionally, we aimed to identify factors influencing these detection rates using binary logistic regression analysis.
UNASSIGNED: Following propensity score matching, a total of 17,862 patients who underwent diagnostic EGD with or without propofol sedation were identified. The group that received sedation exhibited a higher detection rate of precancerous lesions and EC in comparison to the non-sedated group (1.04 vs. 0.75%; p = 0.039). Additionally, within the sedated group, there was an increased likelihood of identifying precancerous lesions and EC specifically at the gastric antrum (0.60 vs. 0.32%, p = 0.006). Binary logistic regression analysis demonstrated that independent risk factors influencing the detection rates included age, gender, observation time, and number of biopsies conducted during the procedure.
UNASSIGNED: Anesthesia assistance during EGD screening proved advantageous in detecting EC as well as precancerous lesions. It is crucial for endoscopists to consider these factors when performing EGD screening procedures.
摘要：
■食管胃十二指肠镜检查（EGD）是早期发现上消化道（UGI）癌症的基本程序。然而,关于EGD期间镇静对识别癌前病变和早期癌症(EC)的影响的研究有限.这项回顾性研究旨在评估EGD期间的镇静是否可以提高癌前病变和EC的检出率。
■在这项倾向得分匹配的回顾性研究中，我们检查了2023年1月至2023年12月在大型三级中心接受诊断性EGD的门诊患者的医疗记录.有关内窥镜检查结果和组织学活检的数据来自内窥镜检查质量控制系统。主要目的是比较EGD期间接受镇静治疗的患者的癌前病变和EC的检出率。那些没有接受镇静剂的人。此外,我们旨在使用二元逻辑回归分析来确定影响这些检出率的因素.
■在倾向得分匹配之后，共发现17,862例接受诊断性EGD伴或不伴丙泊酚镇静的患者.与未镇静组相比，接受镇静组的癌前病变和EC的检出率更高（1.04vs.0.75%；p=0.039）。此外,在镇静的群体中，特别是在胃窦识别癌前病变和EC的可能性增加（0.60vs.0.32%，p=0.006)。二元Logistic回归分析显示,影响检出率的独立危险因素包括年龄、性别,观察时间,以及手术过程中进行的活检数量。
■在EGD筛查期间的麻醉辅助被证明在检测EC以及癌前病变方面是有利的。内镜医师在进行EGD筛查程序时考虑这些因素至关重要。
■在这项倾向得分匹配的回顾性研究中，我们检查了2023年1月至2023年12月在大型三级中心接受诊断性EGD的门诊患者的医疗记录.有关内窥镜检查结果和组织学活检的数据来自内窥镜检查质量控制系统。主要目的是比较EGD期间接受镇静治疗的患者的癌前病变和EC的检出率。那些没有接受镇静剂的人。此外,我们旨在使用二元逻辑回归分析来确定影响这些检出率的因素.
■在倾向得分匹配之后，共发现17,862例接受诊断性EGD伴或不伴丙泊酚镇静的患者.与未镇静组相比，接受镇静组的癌前病变和EC的检出率更高（1.04vs.0.75%；p=0.039）。此外,在镇静的群体中，特别是在胃窦识别癌前病变和EC的可能性增加（0.60vs.0.32%，p=0.006)。二元Logistic回归分析显示,影响检出率的独立危险因素包括年龄、性别,观察时间,以及手术过程中进行的活检数量。
■在EGD筛查期间的麻醉辅助被证明在检测EC以及癌前病变方面是有利的。内镜医师在进行EGD筛查程序时考虑这些因素至关重要。
