PDF(Pubmed)
Abstract：
UNASSIGNED: Altered lipid levels may be associated with the development of a number of malignancies, including cancer of the cervix. However, there is limited understanding of this relationship in the rural Ugandan context.
UNASSIGNED: We investigated the connection between dyslipidaemias and cervical intraepithelial neoplasia (CIN) among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital in south-western Uganda.
UNASSIGNED: This unmatched case-control study was conducted between December 2022 and February 2023 and included women with CIN (cases) and women without intraepithelial lesions (controls) in a 1:1 ratio. Participants were selected based on cytology and/or histology results, and after obtaining written informed consent. Demographic data were collected, and venous blood was drawn for lipid profile analysis. Dyslipidaemia was defined as: total cholesterol > 200 mg/dL, low-density lipoprotein > 160 mg/dL, triglycerides > 150 mg/dL, or high-density lipoprotein < 40 mg/dL. At diagnosis, cases were categorised as either CIN1 (low grade) or CIN2+ (high grade).
UNASSIGNED: Among the 93 cases, 81 had CIN1, while 12 had CIN2+. Controls had a 13.9% (13/93) prevalence of high triglycerides and cases had a prevalence of 3.2% (3/93; p = 0.016). Reduced high-density lipoprotein was the most prevalent dyslipidaemia among cases (40.9%; 38/93). Statistically significant associations were found between high serum triglycerides and CIN (odds ratio: 1.395, 95% confidence interval: 0.084-1.851, p = 0.007).
UNASSIGNED: A notable association was observed between triglyceride dyslipidemia and CIN. Further studies into biochemical processes and interactions between lipids and cervical carcinogenesis are recommended through prospective cohort studies.
UNASSIGNED: This research provides additional information on the potential role of lipids in cervical carcinogenesis among women in rural Uganda. It also presents the possible prevalence of multimorbidity involving cervical cancer and cardiovascular diseases, particularly in low-resource settings lacking preventive measures against the increasing prevalence of dyslipidaemia.
UNASSIGNED: We investigated the connection between dyslipidaemias and cervical intraepithelial neoplasia (CIN) among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital in south-western Uganda.
UNASSIGNED: This unmatched case-control study was conducted between December 2022 and February 2023 and included women with CIN (cases) and women without intraepithelial lesions (controls) in a 1:1 ratio. Participants were selected based on cytology and/or histology results, and after obtaining written informed consent. Demographic data were collected, and venous blood was drawn for lipid profile analysis. Dyslipidaemia was defined as: total cholesterol > 200 mg/dL, low-density lipoprotein > 160 mg/dL, triglycerides > 150 mg/dL, or high-density lipoprotein < 40 mg/dL. At diagnosis, cases were categorised as either CIN1 (low grade) or CIN2+ (high grade).
UNASSIGNED: Among the 93 cases, 81 had CIN1, while 12 had CIN2+. Controls had a 13.9% (13/93) prevalence of high triglycerides and cases had a prevalence of 3.2% (3/93; p = 0.016). Reduced high-density lipoprotein was the most prevalent dyslipidaemia among cases (40.9%; 38/93). Statistically significant associations were found between high serum triglycerides and CIN (odds ratio: 1.395, 95% confidence interval: 0.084-1.851, p = 0.007).
UNASSIGNED: A notable association was observed between triglyceride dyslipidemia and CIN. Further studies into biochemical processes and interactions between lipids and cervical carcinogenesis are recommended through prospective cohort studies.
UNASSIGNED: This research provides additional information on the potential role of lipids in cervical carcinogenesis among women in rural Uganda. It also presents the possible prevalence of multimorbidity involving cervical cancer and cardiovascular diseases, particularly in low-resource settings lacking preventive measures against the increasing prevalence of dyslipidaemia.
摘要：
■脂质水平的改变可能与许多恶性肿瘤的发展有关，包括子宫颈癌.然而,在乌干达农村地区，对这种关系的理解有限。
我们调查了乌干达西南部Mbarara地区转诊医院宫颈癌诊所就诊的女性血脂异常与宫颈上皮内瘤变(CIN)之间的关系。
这项无与伦比的病例对照研究于2022年12月至2023年2月之间进行，以1：1的比例纳入患有CIN（病例）的女性和没有上皮内病变的女性（对照）。根据细胞学和/或组织学结果选择参与者，并在获得书面知情同意书后。收集了人口统计数据，抽取静脉血进行血脂分析。血脂异常定义为：总胆固醇>200mg/dL，低密度脂蛋白>160mg/dL，甘油三酯>150毫克/分升，或高密度脂蛋白<40mg/dL。诊断时,病例分为CIN1(低度)或CIN2+(高度)。
■在93例病例中，81hadCIN1，而12hadCIN2+。对照组的高甘油三酯患病率为13.9%（13/93），病例的患病率为3.2%（3/93；p=0.016）。高密度脂蛋白降低是病例中最常见的血脂异常（40.9％；38/93）。在高血清甘油三酯和CIN之间发现了统计学上显著的关联(比值比:1.395,95%置信区间:0.084-1.851,p=0.007)。
■观察到甘油三酯血脂异常和CIN之间存在显著关联建议通过前瞻性队列研究进一步研究生化过程以及脂质与宫颈癌发生之间的相互作用。
■这项研究提供了有关脂质在乌干达农村妇女宫颈癌发生中的潜在作用的其他信息。它还提出了涉及宫颈癌和心血管疾病的多发病率的可能患病率，特别是在资源匮乏的地区，缺乏针对血脂异常患病率增加的预防措施。
我们调查了乌干达西南部Mbarara地区转诊医院宫颈癌诊所就诊的女性血脂异常与宫颈上皮内瘤变(CIN)之间的关系。
这项无与伦比的病例对照研究于2022年12月至2023年2月之间进行，以1：1的比例纳入患有CIN（病例）的女性和没有上皮内病变的女性（对照）。根据细胞学和/或组织学结果选择参与者，并在获得书面知情同意书后。收集了人口统计数据，抽取静脉血进行血脂分析。血脂异常定义为：总胆固醇>200mg/dL，低密度脂蛋白>160mg/dL，甘油三酯>150毫克/分升，或高密度脂蛋白<40mg/dL。诊断时,病例分为CIN1(低度)或CIN2+(高度)。
■在93例病例中，81hadCIN1，而12hadCIN2+。对照组的高甘油三酯患病率为13.9%（13/93），病例的患病率为3.2%（3/93；p=0.016）。高密度脂蛋白降低是病例中最常见的血脂异常（40.9％；38/93）。在高血清甘油三酯和CIN之间发现了统计学上显著的关联(比值比:1.395,95%置信区间:0.084-1.851,p=0.007)。
■观察到甘油三酯血脂异常和CIN之间存在显著关联建议通过前瞻性队列研究进一步研究生化过程以及脂质与宫颈癌发生之间的相互作用。
■这项研究提供了有关脂质在乌干达农村妇女宫颈癌发生中的潜在作用的其他信息。它还提出了涉及宫颈癌和心血管疾病的多发病率的可能患病率，特别是在资源匮乏的地区，缺乏针对血脂异常患病率增加的预防措施。
