UNASSIGNED: We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m2 during follow-up. To assess air pollution, a PM2.5 exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM2.5 concentrations in residential areas as a risk factor for outcomes.
UNASSIGNED: Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM2.5 concentrations between 16.2 and 33.4 μg/m3 (mean, 22.7 μg/m3) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM2.5 concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m3 increase in PM2.5 for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women.
UNASSIGNED: Elevated PM2.5 did not represent a significant risk factor for incident CKD in a prefecture in Japan.
■我们在茨城县检查了77,770名估计肾小球滤过率(eGFR)≥60ml/min/1.73m2的男性和女性,他们从1993年开始参加了40-75岁的年度社区健康检查,并随访到2020年12月。结果是新出现的肾功能不全,随访期间eGFR<60ml/min/1.73m2。为了评估空气污染,采用PM2.5暴露模型以1×1公里的分辨率估算年均值,转化为市政一级的手段。危险模型用于检查居民区的PM2.5浓度作为结果的风险因素。
■参与者分布在茨城县的23个城市,PM2.5浓度在16.2至33.4μg/m3之间(平均值,22.7μg/m3),1987-1995年为暴露期。随访期间有942例新出现的肾功能障碍。根据1987-1995年的PM2.5浓度作为基线暴露,对于新出现的肾功能不全,PM2.5每增加10μg/m3的多变量校正风险比,男性为1.02(95CI,0.80~1.24),女性为1.19(95CI,0.95~1.44).
■PM2.5升高并不代表日本某县CKD事件的重要危险因素。