PDF(Pubmed)
Abstract：
UNASSIGNED: Excessive daytime sleepiness (EDS) and caudate nucleus volume alterations have been linked to Alzheimer\'s disease (AD), but their relationship remains unclear under the context of subjective cognitive decline (SCD).
UNASSIGNED: This study aimed to investigate the relationship between EDS and caudate nucleus volume in patients with SCD.
UNASSIGNED: The volume of entire brain was measured in 170 patients with SCD, including 37 patients with EDS and 133 non-EDS, from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Participants underwent a comprehensive assessment battery, including neuropsychological and clinical evaluations, blood tests, genetic analysis for APOE ɛ4, and structural MRI scans analyzed using the fully automated segmentation tool, volBrain.
UNASSIGNED: Patients with EDS had significantly increased volume in the total and left caudate nucleus compared to non-EDS. The most significant cognitive behavioral factor associated with caudate nucleus volume in the EDS was the Auditory Verbal Learning Test-recognition.
UNASSIGNED: These findings suggest that EDS may be associated with alterations in caudate nucleus volume, particularly in the left hemisphere, in the context of SCD. Further research is necessary to understand the underlying mechanisms of this relationship and its implications for clinical management.
UNASSIGNED: This study aimed to investigate the relationship between EDS and caudate nucleus volume in patients with SCD.
UNASSIGNED: The volume of entire brain was measured in 170 patients with SCD, including 37 patients with EDS and 133 non-EDS, from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Participants underwent a comprehensive assessment battery, including neuropsychological and clinical evaluations, blood tests, genetic analysis for APOE ɛ4, and structural MRI scans analyzed using the fully automated segmentation tool, volBrain.
UNASSIGNED: Patients with EDS had significantly increased volume in the total and left caudate nucleus compared to non-EDS. The most significant cognitive behavioral factor associated with caudate nucleus volume in the EDS was the Auditory Verbal Learning Test-recognition.
UNASSIGNED: These findings suggest that EDS may be associated with alterations in caudate nucleus volume, particularly in the left hemisphere, in the context of SCD. Further research is necessary to understand the underlying mechanisms of this relationship and its implications for clinical management.
摘要：
■白天过度嗜睡（EDS）和尾状核体积改变与阿尔茨海默病（AD）有关，但在主观认知功能下降(SCD)的背景下,两者的关系仍不清楚.
■本研究旨在探讨SCD患者EDS与尾状核体积的关系。
■测量了170例SCD患者的全脑体积，包括37例EDS和133例非EDS患者，来自中国认知衰退纵向研究(SILCODE)。参与者接受了全面的评估，包括神经心理学和临床评估，验血,对APOE进行遗传分析，并使用全自动分割工具对结构MRI扫描进行分析，volBrain.
■与非EDS相比，EDS患者的总和左尾状核体积明显增加。EDS中与尾状核体积相关的最重要的认知行为因素是听觉语言学习测试识别。
■这些发现表明EDS可能与尾状核体积的改变有关，特别是在左半球，在SCD的背景下。需要进一步的研究来了解这种关系的潜在机制及其对临床管理的影响。
■本研究旨在探讨SCD患者EDS与尾状核体积的关系。
■测量了170例SCD患者的全脑体积，包括37例EDS和133例非EDS患者，来自中国认知衰退纵向研究(SILCODE)。参与者接受了全面的评估，包括神经心理学和临床评估，验血,对APOE进行遗传分析，并使用全自动分割工具对结构MRI扫描进行分析，volBrain.
■与非EDS相比，EDS患者的总和左尾状核体积明显增加。EDS中与尾状核体积相关的最重要的认知行为因素是听觉语言学习测试识别。
■这些发现表明EDS可能与尾状核体积的改变有关，特别是在左半球，在SCD的背景下。需要进一步的研究来了解这种关系的潜在机制及其对临床管理的影响。
