PDF(Pubmed)
Abstract：
UNASSIGNED: There is now increasing evidence that type 2 diabetes mellitus (T2DM) is associated with Alzheimer\'s disease (AD). However, it is unclear whether the two are causally related.
UNASSIGNED: To reveal the causal association between T2DM and AD, we performed a bidirectional Mendelian randomization (MR) analysis.
UNASSIGNED: Genetic instrumental variables were systematically screened, and inverse-variance weighting, MR-Egger regression, weighted median, simple mode, and weighted mode were applied to assess the pathogenic associations between the two diseases, and sensitivity analyses were used to further validate the robustness of the results.
UNASSIGNED: The results of forward MR analysis with T2DM as the exposure were [OR = 0.998, 95% CI (0.975∼1.021), p = 0.857], and the results of reverse MR analysis with AD as the exposure were [OR = 0.966, 95% CI (0.934∼0.999), p = 0.043]. The results showed no significant association between T2DM and AD at the gene level (p < 0.025). Sensitivity analyses were consistent with the results of the main analysis, confirming the robustness of the study.
UNASSIGNED: T2DM and AD may not be genetically causally associated.
UNASSIGNED: To reveal the causal association between T2DM and AD, we performed a bidirectional Mendelian randomization (MR) analysis.
UNASSIGNED: Genetic instrumental variables were systematically screened, and inverse-variance weighting, MR-Egger regression, weighted median, simple mode, and weighted mode were applied to assess the pathogenic associations between the two diseases, and sensitivity analyses were used to further validate the robustness of the results.
UNASSIGNED: The results of forward MR analysis with T2DM as the exposure were [OR = 0.998, 95% CI (0.975∼1.021), p = 0.857], and the results of reverse MR analysis with AD as the exposure were [OR = 0.966, 95% CI (0.934∼0.999), p = 0.043]. The results showed no significant association between T2DM and AD at the gene level (p < 0.025). Sensitivity analyses were consistent with the results of the main analysis, confirming the robustness of the study.
UNASSIGNED: T2DM and AD may not be genetically causally associated.
摘要：
■现在有越来越多的证据表明2型糖尿病（T2DM）与阿尔茨海默病（AD）有关。然而,目前尚不清楚两者是否有因果关系。
■为了揭示T2DM和AD之间的因果关系，我们进行了双向孟德尔随机化(MR)分析.
■系统地筛选了遗传工具变量，和逆方差加权，MR-Egger回归，加权中位数，简单模式，和加权模式用于评估两种疾病之间的致病关联，和敏感性分析用于进一步验证结果的稳健性。
■以T2DM为暴露量的正向MR分析结果为[OR=0.998,95%CI(0.975~1.021),p=0.857]，以AD为暴露量的反向MR分析结果为[OR=0.966,95%CI(0.934~0.999),p=0.043]。结果显示在基因水平上T2DM和AD之间没有显著关联(p<0.025)。敏感性分析与主要分析结果一致，证实了研究的稳健性。
■T2DM和AD可能没有遗传因果关系。
■为了揭示T2DM和AD之间的因果关系，我们进行了双向孟德尔随机化(MR)分析.
■系统地筛选了遗传工具变量，和逆方差加权，MR-Egger回归，加权中位数，简单模式，和加权模式用于评估两种疾病之间的致病关联，和敏感性分析用于进一步验证结果的稳健性。
■以T2DM为暴露量的正向MR分析结果为[OR=0.998,95%CI(0.975~1.021),p=0.857]，以AD为暴露量的反向MR分析结果为[OR=0.966,95%CI(0.934~0.999),p=0.043]。结果显示在基因水平上T2DM和AD之间没有显著关联(p<0.025)。敏感性分析与主要分析结果一致，证实了研究的稳健性。
■T2DM和AD可能没有遗传因果关系。
