PDF(Pubmed)
Abstract：
Noise-induced hearing loss (NIHL) is a significant and urgent global public health concern, arising from prolonged exposure to elevated levels of noise. This auditory impairment harms delicate inner ear structures, particularly the essential hair cells transmitting auditory signals to the brain. Recognized by the World Health Organization as a major contributor to worldwide hearing loss, NIHL requires a comprehensive examination of its molecular and cellular mechanisms. Animal models emerge as indispensable tools for unraveling these intricacies, allowing researchers to simulate and study the impact of noise exposure on auditory structures, shedding light on the interplay of oxidative stress, inflammation and immune responses-crucial factors in NIHL progression. The present review focuses on elucidating the molecular mechanisms of NIHL, with a specific emphasis on findings derived from animal models, alongside the exploration of thorough preventive strategies, including protective measures and probing potential interventions. Understanding the molecular underpinnings not only provides insight into targeted treatment approaches, but also unlocks pathways for exploring and implementing preventive actions. This approach not only deepens the current comprehension of NIHL, but also has the potential to influence the shaping of public health policies, offering a nuanced perspective on this prevalent auditory disorder.
摘要：
噪声性听力损失（NIHL）是一个重要而紧迫的全球公共卫生问题。由于长时间暴露在高水平的噪音中。这种听觉损伤损害了精致的内耳结构，特别是向大脑传递听觉信号的基本毛细胞。被世界卫生组织确认为全球听力损失的主要贡献者，NIHL需要对其分子和细胞机制进行全面检查。动物模型成为解开这些错综复杂的不可或缺的工具，允许研究人员模拟和研究噪声暴露对听觉结构的影响，阐明氧化应激的相互作用，炎症和免疫反应-NIHL进展的关键因素。本文就NIHL的分子机制进行综述,特别强调来自动物模型的发现，在探索全面预防策略的同时，包括保护措施和探测潜在的干预措施。了解分子基础不仅可以深入了解靶向治疗方法，但也为探索和实施预防措施开辟了道路。这种方法不仅加深了目前对NIHL的理解，但也有可能影响公共卫生政策的制定，对这种普遍的听觉障碍提供了细微差别的观点。
