METHODS: In a prospective case-control study, we recruited 100 completely edentulous participants from South India. Participants were categorized based on alveolar ridge height. Saliva samples were non-invasively collected for DNA extraction, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was employed to determine genotype distribution using the HphI restriction enzyme. The statistical evaluations comprised the utilization of chi-square and Fisher\'s exact tests.
RESULTS: We observed no significant variations in genotype distributions between the case and control cohorts (CT: p=0.24; CC: p=0.65; TT: p=0.30). The heterozygous genotype CT was prevalent in both groups.
CONCLUSIONS: Although we did not observe significant associations between SNP 1772C>T and RRR, our findings imply a genetic predisposition to residual ridge resorption that warrants further exploration. Variations in genetic susceptibility across ethnicities and the influence of other genetic variants on residual ridge resorption require additional investigation. This study lays the groundwork for personalized prosthodontic care by highlighting the potential of genetic analysis in routine dental practice to improve treatment strategies.
方法:在一项前瞻性病例对照研究中,我们从印度南部招募了100名完全无牙的参与者.参与者根据牙槽脊高度进行分类。非侵入性收集唾液样本进行DNA提取,和聚合酶链反应限制性片段长度多态性(PCR-RFLP)分析用于确定使用HphI限制性内切酶的基因型分布。统计评价包括卡方检验和Fisher精确检验。
结果:我们观察到病例组和对照组之间基因型分布没有显著差异(CT:p=0.24;CC:p=0.65;TT:p=0.30)。杂合基因型CT在两组中普遍存在。
结论:尽管我们没有观察到SNP1772C>T和RRR之间的显著关联,我们的发现暗示了残余脊吸收的遗传易感性,值得进一步探索。不同种族的遗传易感性变化以及其他遗传变异对残留脊吸收的影响需要进一步研究。这项研究通过强调遗传分析在常规牙科实践中改善治疗策略的潜力,为个性化修复护理奠定了基础。