PDF(Pubmed)
Abstract：
Given that the colon represents the most extensive hormone-responsive tissue in the human body, it prompts a compelling inquiry into whether the progression of its cancer is intimately linked to hormonal dynamics. Consequently, the interplay between sex steroids - a pivotal constituent of hormones - and colorectal cancer has increasingly captivated scientific interest. Upon a comprehensive review of pertinent literature both domestically and internationally, this study delineates the present landscape of three pivotal steroids - estrogen, progestin, and androgen - in the context of colorectal cancer. More specifically, this investigation probes into the potential utility of these steroids in providing therapeutic interventions, diagnostic insights, and prognostic indicators. Furthermore, this study also delves into the mechanistic pathways through which sex steroid interventions exert influence on colorectal cancer. It was discovered that the trio of sex steroid hormones partakes in an array of biological processes, thereby influencing the onset and progression of colorectal cancer. In conclusion, this study posits that a profound interconnection exists between colorectal cancer and sex steroids, suggesting that elucidating the targets of their action mechanisms could unveil novel avenues for the diagnosis and prevention of colorectal cancer.
摘要：
鉴于结肠代表了人体中最广泛的激素反应性组织，它引发了一个令人信服的调查，即癌症的进展是否与荷尔蒙动力学密切相关。因此,性类固醇-激素的关键成分-与结直肠癌之间的相互作用越来越引起科学兴趣。通过对国内外相关文献的全面回顾，这项研究描绘了三种关键类固醇-雌激素的现状，孕激素,和雄激素-在结直肠癌的背景下。更具体地说,这项调查探讨了这些类固醇在提供治疗干预方面的潜在效用，诊断见解，和预后指标。此外，本研究还探讨了性类固醇干预对结直肠癌产生影响的机制途径.人们发现，性类固醇激素的三重奏参与了一系列生物过程，从而影响结直肠癌的发生和进展。总之,这项研究认为结直肠癌和性类固醇之间存在着深刻的联系，这表明阐明其作用机制的靶点可以揭示诊断和预防结直肠癌的新途径.
